Xenografts for tendon and ligament repair

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dc.contributor.author Milthorpe, BK
dc.date.accessioned 2010-05-28T09:50:14Z
dc.date.issued 1994
dc.identifier.citation Biomaterials, 1994, 15 (10), pp. 745 - 752
dc.identifier.issn 0142-9612
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/9526
dc.description.abstract Collagenous materials, usually of bovine or equine origin, have been popular starting points for the development of xenograft prostheses for tendon and ligament repair. Xenografts are highly attractive as they carry small risk of infectious disease, do not compromise the patient's remaining tissues and may have the 'correct' structure as the component being replaced. Animal studies, on dog, rabbit and chicken, have shown tremendous potential for this use of xenograft material as a tendon replacement. Why, therefore, have xenografts been almost universally a total failure in clinical application? The reasons would appear to be two-fold: the animal models have not been appropriate to the intended clinical use and the cross-linking of xenograft materials has not been optimized. Our work on xenograft, heterograft and autograft tissues indicates that both aspects deserve more attention. Quantitative histology indicates that the extent and type of response to xenograft materials differs widely with degree of cross-linking (glutaraldehyde). Attention must also be given to the join of the graft to the host. For both tendon and ligament the join is a site of particular fragility. Even with adequate strength in the mid-substance, tendon and ligament grafts can, and do, fail at the join. We have investigated a variety of mechanisms for joining tendon to tendon and ligaments to bone. The failures of these methods present some insight into the biology of the repair process involved and into how failure may be avoided in future. Biomaterials (1994) 15, (10) 745-752. © 1994.
dc.language eng
dc.relation.isbasedon 10.1016/0142-9612(94)90027-2
dc.title Xenografts for tendon and ligament repair
dc.type Journal Article
dc.parent Biomaterials
dc.journal.volume 10
dc.journal.volume 15
dc.journal.number 10 en_US
dc.publocation Oxford, UK en_US
dc.identifier.startpage 745 en_US
dc.identifier.endpage 752 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 090302 Biomechanical Engineering
dc.for 090301 Biomaterials
dc.for 110304 Dermatology
dc.personcode 105631
dc.percentage 40 en_US
dc.classification.name Dermatology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords collagen
dc.description.keywords glutaraldehyde
dc.description.keywords ligaments
dc.description.keywords tendons
dc.description.keywords Xenografts
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)

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