Elemental bio-imaging of melanoma in lymph node biopsies.

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dc.contributor.author Hare, D
dc.contributor.author Burger, F
dc.contributor.author Austin, C
dc.contributor.author Fryer, F
dc.contributor.author Grimm, R
dc.contributor.author Reedy, B
dc.contributor.author Scolyer, RA
dc.contributor.author Thompson, JF
dc.contributor.author Doble, P
dc.date.accessioned 2010-05-28T09:50:57Z
dc.date.issued 2009-03
dc.identifier.citation The Analyst, 2009, 134 (3), pp. 450 - 453
dc.identifier.issn 0003-2654
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/9644
dc.description.abstract The spatial distribution of trace elements in human lymph nodes partially infiltrated by melanoma cells was determined by elemental bio-imaging. Imaging of (31)P within the nodal capsule and normal lymph node tissue showed a clear demarcation of the tumour boundary, with a significant decrease in relative (31)P concentration within the tumour. The location of the tumour boundary was confirmed by haematoxylin and eosin staining of serial sections and observation by light microscopy. Further enhancement of the tumour boundary was achieved by imaging the (31)P/(34)S ratio. (31)P/(66)Zn ratio images showed a decreasing ratio beyond the tumour boundary that extended into peritumour normal lymph node tissue.
dc.format Print-Electronic
dc.language eng
dc.relation.hasversion Accepted manuscript version en_US
dc.relation.isbasedon 10.1039/b812745j
dc.subject Humans, Melanoma, Lymphatic Metastasis, Phosphorus, Trace Elements, Sentinel Lymph Node Biopsy, Tumor Markers, Biological, Mass Spectrometry, Humans, Lymphatic Metastasis, Mass Spectrometry, Melanoma, Phosphorus, Sentinel Lymph Node Biopsy, Trace Elements, Tumor Markers, Biological, Analytical Chemistry
dc.subject Humans; Melanoma; Lymphatic Metastasis; Phosphorus; Trace Elements; Sentinel Lymph Node Biopsy; Tumor Markers, Biological; Mass Spectrometry; Humans; Lymphatic Metastasis; Mass Spectrometry; Melanoma; Phosphorus; Sentinel Lymph Node Biopsy; Trace Elements; Tumor Markers, Biological; Analytical Chemistry
dc.title Elemental bio-imaging of melanoma in lymph node biopsies.
dc.type Journal Article
dc.parent The Analyst
dc.journal.volume 3
dc.journal.volume 134
dc.journal.number 3 en_US
dc.publocation Cambridge, UK en_US
dc.identifier.startpage 450 en_US
dc.identifier.endpage 453 en_US
dc.cauo.name SCI.Chemistry and Forensic Sciences en_US
dc.conference Verified OK en_US
dc.for 0399 Other Chemical Sciences
dc.personcode 995243 en_US
dc.personcode 0000041658 en_US
dc.personcode 998392 en_US
dc.personcode 84151444 en_US
dc.personcode 0000048940 en_US
dc.personcode 000263 en_US
dc.personcode 0000020026 en_US
dc.personcode X000017029 en_US
dc.personcode 010494 en_US
dc.percentage 100 en_US
dc.classification.name Other Chemical Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords en_US
dc.description.keywords Humans
dc.description.keywords Melanoma
dc.description.keywords Lymphatic Metastasis
dc.description.keywords Phosphorus
dc.description.keywords Trace Elements
dc.description.keywords Sentinel Lymph Node Biopsy
dc.description.keywords Tumor Markers, Biological
dc.description.keywords Mass Spectrometry
dc.staffid 010494 en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Faculty of Science/School of Chemistry and Forensic Science
pubs.organisational-group /University of Technology Sydney/Strength - Forensic Science


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