The alginate regulator AlgR and an associated sensor FimS are required for twitching motility in Pseudomonas aeruginosa

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dc.contributor.author Whitchurch, CB
dc.contributor.author Alm, RA
dc.contributor.author Mattick, JS
dc.date.accessioned 2010-05-28T09:51:43Z
dc.date.issued 1996-09-03
dc.identifier.citation Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 (18), pp. 9839 - 9843
dc.identifier.issn 0027-8424
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/9767
dc.description.abstract Mucoid strains of Pseudomonas aeruginosa isolated from the lungs of cystic fibrosis patients produce large amounts of the exopolysaccharide alginate. AlgR has long been considered a key regulator of alginate production, but its cognate sensor has not been identified. Here we show that AlgR is required for twitching motility, which is a form of bacterial surface translocation mediated by type 4 fimbriae. Adjacent to algR we have identified a sensor gene (fimS), which is also required for twitching motility. However, FimS does not appear to be required for alginate production in mucoid strains. FimS and AlgR are representative of a new subclass of two-component transmitter-receiver regulatory systems. The alternative sigma factor AlgU also affects both alginate production and twitching motility. Therefore, these two virulence determinants appear to be closely associated and coordinately regulated.
dc.language eng
dc.relation.isbasedon 10.1073/pnas.93.18.9839
dc.title The alginate regulator AlgR and an associated sensor FimS are required for twitching motility in Pseudomonas aeruginosa
dc.type Journal Article
dc.parent Proceedings of the National Academy of Sciences of the United States of America
dc.journal.volume 18
dc.journal.volume 93
dc.journal.number 18 en_US
dc.publocation Washington, USA en_US
dc.identifier.startpage 9839 en_US
dc.identifier.endpage 9843 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 1108 Medical Microbiology
dc.personcode 103745
dc.percentage 100 en_US
dc.classification.name Medical Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:A1996VF61400094 en_US
dc.description.keywords cystic fibrosis
dc.description.keywords fimbriae
dc.description.keywords pathogenesis
dc.description.keywords pili
dc.description.keywords twitching motility
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)


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