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Issue DateTitleAuthor(s)
Jan-2007Peptidases of Trichobilharzia regenti (Schistosomatidae) and its molluscan host Radix peregra s.lat. (Lymnaeidae) Construction and screening of cDNA library from intramolluscan stages of the parasiteDoleckova, K; Kasny, M; Mikes, L; Mutapi, F; Stack, CM; Mountford, A; Horak, P
20-Jan-2006Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites: Target for the antimalarial activity of bestatinGardiner, DL; Trenholme, KR; Skinner-Adams, TS; Stack, CM; Dalton, JP
18-Sep-2006Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepaticaSekiya, M; Mulcahy, G; Irwin, JA; Stack, CM; Donnelly, SM; Xu, W; Collins, P; Dalton, JP
1-Sep-2005De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serumStack, CM; Dalton, JP; Cunneen, M; Donnelly, S
16-Jun-2009The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: Importance of active site metal ions in the binding of substrates and inhibitorsMaric, S; Donnelly, SM; Robinson, MW; Skinner-Adams, T; Trenholme, KR; Gardiner, DL; Dalton, JP; Stack, CM; Lowther, J
24-Feb-2009Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidaseMcGowan, S; Porter, CJ; Lowther, J; Stack, CM; Golding, SJ; Skinner-Adams, TS; Trenholme, KR; Teuscher, F; Donnelly, SM; Grembecka, J; Mucha, A; Kafarski, P; Degori, R; Buckle, AM; Gardiner, DL; Whisstock, JC; Dalton, JP
1-Jun-2007The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: A Leu<sup>-12</sup> to Pro<sup>-12</sup> replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removalStack, CM; Donnelly, S; Lowther, J; Xu, W; Collins, PR; Brinen, LS; Dalton, JP
9-Feb-2010Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidasesMcGowan, S; Oellig, CA; Birru, WA; Caradoc-Davies, TT; Stack, CM; Lowther, J; Skinner-Adams, T; Mucha, A; Kafarski, P; Grembecka, J; Trenholme, KR; Buckle, AM; Gardiner, DL; Dalton, JP; Whisstock, JC
23-Apr-2004Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: Propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cellsCollins, PR; Stack, CM; O'Neill, SM; Doyle, S; Ryan, T; Brennan, GP; Mousley, A; Stewart, M; Maule, AG; Dalton, JP; Donnelly, S
29-Nov-2007Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compoundsSkinner-Adams, TS; Lowther, J; Teuscher, F; Stack, CM; Grembecka, J; Mucha, A; Kafarski, P; Trenholme, KR; Dalton, JP; Gardiner, DL
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