TY - JOUR AB - Novel laudanosine dimers in which two laudanosine units are linked at C-2? via a two and four-carbon linker have been prepared using ruthenium-mediated olefin-metathesis. In addition, a second four-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system. Five of these compounds showed higher cytostatic activity on three cancer cell lines than thalicarpine. Crown Copyright © 2009. AU - Mbere-Nguyen, U AU - Ung, AT AU - Pyne, SG DA - 2009/08/01 DO - 10.1016/j.tet.2009.05.094 EP - 6000 JO - Tetrahedron PY - 2009/08/01 SP - 5990 TI - The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis VL - 65 Y1 - 2009/08/01 Y2 - 2024/03/28 ER -