Sulfur - fluorine bond in PET radiochemistry.

Pascali, G; Matesic, L; Zhang, B; King, AT; Robinson, AJ; Ung, AT; Fraser, BH

Sulfur - fluorine bond in PET radiochemistry.

Pascali, G

Matesic, L Zhang, B King, AT

Robinson, AJ Ung, AT

Fraser, BH

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Publication Type:: Journal Article
Citation:: EJNMMI Radiopharm Chem, 2017, 2 (1), pp. 9 - ?
Issue Date:: 2017

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Field	Value	Language
dc.contributor.author	Pascali, G https://orcid.org/0000-0001-7919-8416	en_US
dc.contributor.author	Matesic, L	en_US
dc.contributor.author	Zhang, B	en_US
dc.contributor.author	King, AT https://orcid.org/0000-0003-4843-6391	en_US
dc.contributor.author	Robinson, AJ	en_US
dc.contributor.author	Ung, AT https://orcid.org/0000-0002-5665-0702	en_US
dc.contributor.author	Fraser, BH	en_US
dc.date.available	2017-06-14	en_US
dc.date.issued	2017	en_US
dc.identifier.citation	EJNMMI Radiopharm Chem, 2017, 2 (1), pp. 9 - ?	en_US
dc.identifier.uri	http://hdl.handle.net/10453/114688
dc.description.abstract	The importance of the sulfur-fluorine bond is starting to increase in modern medicinal chemistry literature. This is due to a better understanding of the stability and reactivity of this moiety depending on the various oxidation states of sulfur. Furthermore, several commercial reagents used for mild and selective fluorination of organic molecules are based on the known reactivity of S-F groups. In this review, we will show how these examples are translating into the 18F field, both for use as stable tags in finished radiopharmaceuticals and as mildly reactive fluoride-relay intermediates. Finally, we also discuss current opportunities where examples of non-radioactive S-F applications/chemistry may be translated into future 18F radiochemistry applications.	en_US
dc.language	eng	en_US
dc.relation.ispartof	EJNMMI Radiopharm Chem	en_US
dc.relation.isbasedon	10.1186/s41181-017-0028-6	en_US
dc.title	Sulfur - fluorine bond in PET radiochemistry.	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	2	en_US
utslib.location.activity	England	en_US
utslib.for	0301 Analytical Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	2	en_US

Abstract:

The importance of the sulfur-fluorine bond is starting to increase in modern medicinal chemistry literature. This is due to a better understanding of the stability and reactivity of this moiety depending on the various oxidation states of sulfur. Furthermore, several commercial reagents used for mild and selective fluorination of organic molecules are based on the known reactivity of S-F groups. In this review, we will show how these examples are translating into the 18F field, both for use as stable tags in finished radiopharmaceuticals and as mildly reactive fluoride-relay intermediates. Finally, we also discuss current opportunities where examples of non-radioactive S-F applications/chemistry may be translated into future 18F radiochemistry applications.

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http://hdl.handle.net/10453/114688