Mindfulness-based stress reduction for breast cancer- A systematic review and meta-analysis

Cramer, H; Lauche, R; Paul, A; Dobos, G

Mindfulness-based stress reduction for breast cancer- A systematic review and meta-analysis

Cramer, H

Lauche, R

Paul, A Dobos, G

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Publication Type:: Journal Article
Citation:: Current Oncology, 2012, 19 (5)
Issue Date:: 2012-10-09

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Field	Value	Language
dc.contributor.author	Cramer, H https://orcid.org/0000-0002-3640-8046	en_US
dc.contributor.author	Lauche, R https://orcid.org/0000-0002-4171-7935	en_US
dc.contributor.author	Paul, A	en_US
dc.contributor.author	Dobos, G	en_US
dc.date.issued	2012-10-09	en_US
dc.identifier.citation	Current Oncology, 2012, 19 (5)	en_US
dc.identifier.issn	1198-0052	en_US
dc.identifier.uri	http://hdl.handle.net/10453/114810
dc.description.abstract	Objective The aim of this systematic review and meta-analysis was to assess the effectiveness of mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) in patients with breast cancer. Methods The medline, Cochrane Library, embase, cambase, and PsycInfo databases were screened through November 2011. The search strategy combined keywords for MBSR and MBCT with keywords for breast cancer. Randomized controlled trials (RCTs) comparing MBSR or MBCT with control conditions in patients with breast cancer were included. Two authors independently used the Cochrane risk of bias tool to assess risk of bias in the selected studies. Study characteristics and outcomes were extracted by two authors independently. Primary outcome measures were health-related quality of life and psychological health. If at least two studies assessing an outcome were available, standardized mean differences (SMDS) and 95% confidence intervals (CIs) were calculated for that outcome. As a measure of heterogeneity, I 2 was calculated. Results Three RCTs with a total of 327 subjects were included. One RCT compared MBSR with usual care, one RCT compared MBSR with free-choice stress management, and a three-arm RCT compared MBSR with usual care and with nutrition education. Compared with usual care, MBSR was superior in decreasing depression (SMD: -0.37; 95% CI: -0.65 to -0.08; p = 0.01; I 2 = 0%) and anxiety (SMD: -0.51; 95% CI: -0.80 to -0.21; p = 0.0009; I 2 = 0%), but not in increasing spirituality (SMD: 0.27; 95% CI: -0.37 to 0.91; p = 0.41; I 2 = 79%). Conclusions There is some evidence for the effectiveness of MBSR in improving psychological health in breast cancer patients, but more RCTs are needed to underpin those results. © 2012 Multimed Inc.	en_US
dc.relation.ispartof	Current Oncology	en_US
dc.relation.isbasedon	10.3747/co.19.1016	en_US
dc.subject.classification	Oncology & Carcinogenesis	en_US
dc.title	Mindfulness-based stress reduction for breast cancer- A systematic review and meta-analysis	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	19	en_US
utslib.for	1117 Public Health and Health Services	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	open_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	19	en_US

Abstract:

Objective The aim of this systematic review and meta-analysis was to assess the effectiveness of mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) in patients with breast cancer. Methods The medline, Cochrane Library, embase, cambase, and PsycInfo databases were screened through November 2011. The search strategy combined keywords for MBSR and MBCT with keywords for breast cancer. Randomized controlled trials (RCTs) comparing MBSR or MBCT with control conditions in patients with breast cancer were included. Two authors independently used the Cochrane risk of bias tool to assess risk of bias in the selected studies. Study characteristics and outcomes were extracted by two authors independently. Primary outcome measures were health-related quality of life and psychological health. If at least two studies assessing an outcome were available, standardized mean differences (SMDS) and 95% confidence intervals (CIs) were calculated for that outcome. As a measure of heterogeneity, I 2 was calculated. Results Three RCTs with a total of 327 subjects were included. One RCT compared MBSR with usual care, one RCT compared MBSR with free-choice stress management, and a three-arm RCT compared MBSR with usual care and with nutrition education. Compared with usual care, MBSR was superior in decreasing depression (SMD: -0.37; 95% CI: -0.65 to -0.08; p = 0.01; I 2 = 0%) and anxiety (SMD: -0.51; 95% CI: -0.80 to -0.21; p = 0.0009; I 2 = 0%), but not in increasing spirituality (SMD: 0.27; 95% CI: -0.37 to 0.91; p = 0.41; I 2 = 79%). Conclusions There is some evidence for the effectiveness of MBSR in improving psychological health in breast cancer patients, but more RCTs are needed to underpin those results. © 2012 Multimed Inc.

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