Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition.

Allen, JC; Seidel, P; Schlosser, T; Ramsay, EE; Ge, Q; Ammit, AJ

Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition.

Allen, JC Seidel, P Schlosser, T Ramsay, EE Ge, Q Ammit, AJ

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Publication Type:: Journal Article
Citation:: J Allergy (Cairo), 2012, 2012 pp. 307838 - ?
Issue Date:: 2012

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Field	Value	Language
dc.contributor.author	Allen, JC	en_US
dc.contributor.author	Seidel, P	en_US
dc.contributor.author	Schlosser, T	en_US
dc.contributor.author	Ramsay, EE	en_US
dc.contributor.author	Ge, Q	en_US
dc.contributor.author	Ammit, AJ https://orcid.org/0000-0003-0555-2544	en_US
dc.date.available	2011-11-17	en_US
dc.date.issued	2012	en_US
dc.identifier.citation	J Allergy (Cairo), 2012, 2012 pp. 307838 - ?	en_US
dc.identifier.uri	http://hdl.handle.net/10453/114880
dc.description.abstract	Hyperplasia of airway smooth muscle (ASM) is a feature of the remodelled airway in asthmatics. We examined the antiproliferative effectiveness of the corticosteroid dexamethasone on expression of the key regulator of G(1) cell cycle progression-cyclin D1-in ASM cells from nonasthmatics and asthmatics stimulated with the mitogen platelet-derived growth factor BB. While cyclin D1 mRNA and protein expression were repressed in cells from nonasthmatics in contrast, cyclin D1 expression in asthmatics was resistant to inhibition by dexamethasone. This was independent of a repressive effect on glucocorticoid receptor translocation. Our results corroborate evidence demonstrating that corticosteroids inhibit mitogen-induced proliferation only in ASM cells from subjects without asthma and suggest that there are corticosteroid-insensitive proliferative pathways in asthmatics.	en_US
dc.language	eng	en_US
dc.relation.ispartof	J Allergy (Cairo)	en_US
dc.relation.isbasedon	10.1155/2012/307838	en_US
dc.title	Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition.	en_US
dc.type	Journal Article
utslib.citation.volume	2012	en_US
utslib.location.activity	United States	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	2012	en_US

Abstract:

Hyperplasia of airway smooth muscle (ASM) is a feature of the remodelled airway in asthmatics. We examined the antiproliferative effectiveness of the corticosteroid dexamethasone on expression of the key regulator of G(1) cell cycle progression-cyclin D1-in ASM cells from nonasthmatics and asthmatics stimulated with the mitogen platelet-derived growth factor BB. While cyclin D1 mRNA and protein expression were repressed in cells from nonasthmatics in contrast, cyclin D1 expression in asthmatics was resistant to inhibition by dexamethasone. This was independent of a repressive effect on glucocorticoid receptor translocation. Our results corroborate evidence demonstrating that corticosteroids inhibit mitogen-induced proliferation only in ASM cells from subjects without asthma and suggest that there are corticosteroid-insensitive proliferative pathways in asthmatics.

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http://hdl.handle.net/10453/114880