Dissolution behaviour of aceclofenac-PVP coprecipitates

Dua, K; Pabreja, K; Gorajana, A

Dissolution behaviour of aceclofenac-PVP coprecipitates

Dua, K

Pabreja, K Gorajana, A

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Publication Type:: Journal Article
Citation:: Ars Pharmaceutica, 2012, 53 (3), pp. 7 - 12
Issue Date:: 2012-11-21

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Field	Value	Language
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.contributor.author	Pabreja, K	en_US
dc.contributor.author	Gorajana, A	en_US
dc.date.issued	2012-11-21	en_US
dc.identifier.citation	Ars Pharmaceutica, 2012, 53 (3), pp. 7 - 12	en_US
dc.identifier.issn	0004-2927	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115766
dc.description.abstract	Aim: The objective of the present investigation was to study the effect of PVP on in vitro dissolution of aceclofenac from coprecipitates. Materials and Methods: Aceclofenac coprecipitates (CP) with different drug loadings were prepared and in vitro dissolution studies of pure drug, physical mixtures and coprecipitates were carried out. Results: Coprecipitates of aceclofenac with PVP showed considerable increase in the dissolution rate in comparison with physical mixture and pure drug in 0.1 N HCl, pH1.2 and phosphate buffer, pH, 7.4. Coprecipitates in 1:2 ratio showed maximum dissolution rate in comparison to other ratios. Amorphous nature of the drug in coprecipitates was confirmed by scanning electron microscopy and a decrease in enthalpy of drug melting in coprecipitates compared to the pure drug. FT- IR spectroscopy and differential scanning calorimetry studies indicated no interaction between aceclofenac and PVP in coprecipitates in solid state. Dissolution enhancement was attributed to decreased crystallinity of the drug and to the wetting, eutectic formation and solubilizing effect of the carrier from the coprecipitates of aceclofenac. Conclusion: dissolution of aceclofenac can be enhanced by the use of hydrophilic carriers like PVP.	en_US
dc.relation.ispartof	Ars Pharmaceutica	en_US
dc.subject.classification	Pharmacology & Pharmacy	en_US
dc.title	Dissolution behaviour of aceclofenac-PVP coprecipitates	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	53	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	open_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	53	en_US

Abstract:

Aim: The objective of the present investigation was to study the effect of PVP on in vitro dissolution of aceclofenac from coprecipitates. Materials and Methods: Aceclofenac coprecipitates (CP) with different drug loadings were prepared and in vitro dissolution studies of pure drug, physical mixtures and coprecipitates were carried out. Results: Coprecipitates of aceclofenac with PVP showed considerable increase in the dissolution rate in comparison with physical mixture and pure drug in 0.1 N HCl, pH1.2 and phosphate buffer, pH, 7.4. Coprecipitates in 1:2 ratio showed maximum dissolution rate in comparison to other ratios. Amorphous nature of the drug in coprecipitates was confirmed by scanning electron microscopy and a decrease in enthalpy of drug melting in coprecipitates compared to the pure drug. FT- IR spectroscopy and differential scanning calorimetry studies indicated no interaction between aceclofenac and PVP in coprecipitates in solid state. Dissolution enhancement was attributed to decreased crystallinity of the drug and to the wetting, eutectic formation and solubilizing effect of the carrier from the coprecipitates of aceclofenac. Conclusion: dissolution of aceclofenac can be enhanced by the use of hydrophilic carriers like PVP.

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http://hdl.handle.net/10453/115766