Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle.

Publisher:
Elsevier
Publication Type:
Journal Article
Citation:
Microbes and Infection, 2014, 16 (8), pp. 690 - 694
Issue Date:
2014-08
Full metadata record
Files in This Item:
Filename Description Size
Evidence of a conserved role for Chlamydia HtrA in the replication phase of.pdfPublished Version2.33 MB
Adobe PDF
Identification of the HtrA inhibitor JO146 previously enabled us to demonstrate an essential function for HtrA during the mid-replicative phase of the Chlamydia trachomatis developmental cycle. Here we extend our investigations to other members of the Chlamydia genus. C. trachomatis isolates with distinct replicative phase growth kinetics showed significant loss of viable infectious progeny after HtrA was inhibited during the replicative phase. Mid-replicative phase addition of JO146 was also significantly detrimental to Chlamydia pecorum, Chlamydia suis and Chlamydia cavie. These data combined indicate that HtrA has a conserved critical role during the replicative phase of the chlamydial developmental cycle.
Please use this identifier to cite or link to this item: