Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle

Patel, P; De Boer, L; Timms, P; Huston, WM

Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle

Patel, P De Boer, L Timms, P Huston, WM

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Publication Type:: Journal Article
Citation:: Microbes and Infection, 2014, 16 (8), pp. 690 - 694
Issue Date:: 2014-01-01

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Field	Value	Language
dc.contributor.author	Patel, P	en_US
dc.contributor.author	De Boer, L	en_US
dc.contributor.author	Timms, P	en_US
dc.contributor.author	Huston, WM https://orcid.org/0000-0002-0879-1287	en_US
dc.date.available	2014-07-12	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Microbes and Infection, 2014, 16 (8), pp. 690 - 694	en_US
dc.identifier.issn	1286-4579	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115919
dc.description.abstract	Identification of the HtrA inhibitor JO146 previously enabled us to demonstrate an essential function for HtrA during the mid-replicative phase of the Chlamydia trachomatis developmental cycle. Here we extend our investigations to other members of the Chlamydia genus. C. trachomatis isolates with distinct replicative phase growth kinetics showed significant loss of viable infectious progeny after HtrA was inhibited during the replicative phase. Mid-replicative phase addition of JO146 was also significantly detrimental to Chlamydia pecorum, Chlamydia suis and Chlamydia cavie. These data combined indicate that HtrA has a conserved critical role during the replicative phase of the chlamydial developmental cycle. © 2014 Institut Pasteur.	en_US
dc.relation.ispartof	Microbes and Infection	en_US
dc.relation.isbasedon	10.1016/j.micinf.2014.07.003	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Chlamydia	en_US
dc.subject.mesh	Bacterial Proteins	en_US
dc.subject.mesh	Protease Inhibitors	en_US
dc.subject.mesh	Microbial Viability	en_US
dc.subject.mesh	Serine Proteases	en_US
dc.title	Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	16	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1107 Immunology	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	16	en_US

Abstract:

Identification of the HtrA inhibitor JO146 previously enabled us to demonstrate an essential function for HtrA during the mid-replicative phase of the Chlamydia trachomatis developmental cycle. Here we extend our investigations to other members of the Chlamydia genus. C. trachomatis isolates with distinct replicative phase growth kinetics showed significant loss of viable infectious progeny after HtrA was inhibited during the replicative phase. Mid-replicative phase addition of JO146 was also significantly detrimental to Chlamydia pecorum, Chlamydia suis and Chlamydia cavie. These data combined indicate that HtrA has a conserved critical role during the replicative phase of the chlamydial developmental cycle. © 2014 Institut Pasteur.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/115919