Development and anti-microbial potential of topical formulations containing Cocos nucifera Linn

Sheshala, R; Ying, LT; Hui, LS; Barua, A; Dua, K

Development and anti-microbial potential of topical formulations containing Cocos nucifera Linn

Sheshala, R Ying, LT Hui, LS Barua, A Dua, K

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Publication Type:: Journal Article
Citation:: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry, 2013, 12 (3), pp. 253 - 264
Issue Date:: 2013-12-01

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Field	Value	Language
dc.contributor.author	Sheshala, R	en_US
dc.contributor.author	Ying, LT	en_US
dc.contributor.author	Hui, LS	en_US
dc.contributor.author	Barua, A	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.date.available	2013-05-31	en_US
dc.date.issued	2013-12-01	en_US
dc.identifier.citation	Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry, 2013, 12 (3), pp. 253 - 264	en_US
dc.identifier.issn	1871-5230	en_US
dc.identifier.uri	http://hdl.handle.net/10453/117354
dc.description.abstract	In order to achieve better treatment for local wounds and bacterial infections, topical formulations containing Cocos nucifera Linn. were developed. These formulations were evaluated for their physicochemical properties and antimicrobial efficacy against various strains of microorganisms. Semisolid formulations containing 5% w/w of Cocos nucifera Linn. were prepared by employing different dermatological bases and were evaluated for their physical appearance, pH, rheological properties, FTIR-spectroscopic analysis, thermodynamic stability and stability studies. The antimicrobial activity of each prepared formulation was determined using disk-diffusion method against various strains of microorganisms. All the prepared formulations were found to be stable and exhibited suitable physicochemical characteristics including pH, viscosity and spreadability which are necessary for an ideal topical preparation, in addition to strong antimicrobial activity. Carbopol gel base was found to be the most suitable dermatological base for Cocos nucifera Linn. in comparsion to other bases. Cocos nucifera Linn. formulations showed great potential for wounds and local bacterial infections. Moreover, carbopol gel base with its aesthetic appeal was found to be a suitable dermatological base for Cocos nucifera Linn. semisolid formulation as it had demonstrated significant physicochemical properties and greater diffusion when assessed using disk-diffusion method. © 2013 Bentham Science Publishers.	en_US
dc.relation.ispartof	Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry	en_US
dc.relation.isbasedon	10.2174/18715230113129990012	en_US
dc.subject.classification	Medicinal & Biomolecular Chemistry	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Cocos	en_US
dc.subject.mesh	Plant Oils	en_US
dc.subject.mesh	Gels	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Spectroscopy, Fourier Transform Infrared	en_US
dc.subject.mesh	Bacteriological Techniques	en_US
dc.subject.mesh	Administration, Topical	en_US
dc.subject.mesh	Rheology	en_US
dc.subject.mesh	Drug Stability	en_US
dc.subject.mesh	Chemistry, Pharmaceutical	en_US
dc.subject.mesh	Hydrogen-Ion Concentration	en_US
dc.subject.mesh	Viscosity	en_US
dc.subject.mesh	Hot Temperature	en_US
dc.subject.mesh	Skin Cream	en_US
dc.title	Development and anti-microbial potential of topical formulations containing Cocos nucifera Linn	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	12	en_US
utslib.for	1107 Immunology	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	12	en_US

Abstract:

In order to achieve better treatment for local wounds and bacterial infections, topical formulations containing Cocos nucifera Linn. were developed. These formulations were evaluated for their physicochemical properties and antimicrobial efficacy against various strains of microorganisms. Semisolid formulations containing 5% w/w of Cocos nucifera Linn. were prepared by employing different dermatological bases and were evaluated for their physical appearance, pH, rheological properties, FTIR-spectroscopic analysis, thermodynamic stability and stability studies. The antimicrobial activity of each prepared formulation was determined using disk-diffusion method against various strains of microorganisms. All the prepared formulations were found to be stable and exhibited suitable physicochemical characteristics including pH, viscosity and spreadability which are necessary for an ideal topical preparation, in addition to strong antimicrobial activity. Carbopol gel base was found to be the most suitable dermatological base for Cocos nucifera Linn. in comparsion to other bases. Cocos nucifera Linn. formulations showed great potential for wounds and local bacterial infections. Moreover, carbopol gel base with its aesthetic appeal was found to be a suitable dermatological base for Cocos nucifera Linn. semisolid formulation as it had demonstrated significant physicochemical properties and greater diffusion when assessed using disk-diffusion method. © 2013 Bentham Science Publishers.

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http://hdl.handle.net/10453/117354