Diseases in children born to mothers with preeclampsia: A population-based sibling cohort study

Wu, CS; Nohr, EA; Bech, BH; Vestergaard, M; Catov, JM; Olsen, J

Diseases in children born to mothers with preeclampsia: A population-based sibling cohort study

Wu, CS Nohr, EA Bech, BH Vestergaard, M Catov, JM Olsen, J

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Publication Type:: Journal Article
Citation:: American Journal of Obstetrics and Gynecology, 2011, 204 (2), pp. 157.e1 - 157.e5
Issue Date:: 2011-01-01

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Field	Value	Language
dc.contributor.author	Wu, CS	en_US
dc.contributor.author	Nohr, EA	en_US
dc.contributor.author	Bech, BH	en_US
dc.contributor.author	Vestergaard, M	en_US
dc.contributor.author	Catov, JM	en_US
dc.contributor.author	Olsen, J	en_US
dc.date.available	2010-08-24	en_US
dc.date.issued	2011-01-01	en_US
dc.identifier.citation	American Journal of Obstetrics and Gynecology, 2011, 204 (2), pp. 157.e1 - 157.e5	en_US
dc.identifier.issn	0002-9378	en_US
dc.identifier.uri	http://hdl.handle.net/10453/117390
dc.description.abstract	Objective We previously reported associations between preeclampsia and the occurrence of metabolic and respiratory diseases in the offspring. In this article we examine whether the associations were due to preeclampsia or factors leading to preeclampsia. Study Design From 1978 through 2004, we identified 22,264 discordant sib-pairs in Denmark according to prenatal exposure to preeclampsia. Exposed children were compared to their unexposed siblings by using stratified Cox regression to estimate hazard ratios and 95% confidence intervals for metabolic and respiratory diseases. Results Exposed children had rather similar risks for metabolic disorders compared to their unexposed siblings. However, when the second child within each sib-pair was exposed, this child had an increased risk for respiratory diseases (hazard ratio, 1.55; 95% confidence interval, 1.202.01). Conclusion Factors leading to preeclampsia may shape susceptibility to metabolic or respiratory diseases in the offspring but a programming effect on respiratory diseases induced by preeclampsia cannot be ruled out. © 2011 Mosby, Inc.	en_US
dc.relation.ispartof	American Journal of Obstetrics and Gynecology	en_US
dc.relation.isbasedon	10.1016/j.ajog.2010.08.046	en_US
dc.subject.classification	Obstetrics & Reproductive Medicine	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Respiratory Tract Diseases	en_US
dc.subject.mesh	Pre-Eclampsia	en_US
dc.subject.mesh	Prenatal Exposure Delayed Effects	en_US
dc.subject.mesh	Metabolic Diseases	en_US
dc.subject.mesh	Regression Analysis	en_US
dc.subject.mesh	Cohort Studies	en_US
dc.subject.mesh	Smoking	en_US
dc.subject.mesh	Siblings	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Denmark	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Diseases in children born to mothers with preeclampsia: A population-based sibling cohort study	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	204	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	204	en_US

Abstract:

Objective We previously reported associations between preeclampsia and the occurrence of metabolic and respiratory diseases in the offspring. In this article we examine whether the associations were due to preeclampsia or factors leading to preeclampsia. Study Design From 1978 through 2004, we identified 22,264 discordant sib-pairs in Denmark according to prenatal exposure to preeclampsia. Exposed children were compared to their unexposed siblings by using stratified Cox regression to estimate hazard ratios and 95% confidence intervals for metabolic and respiratory diseases. Results Exposed children had rather similar risks for metabolic disorders compared to their unexposed siblings. However, when the second child within each sib-pair was exposed, this child had an increased risk for respiratory diseases (hazard ratio, 1.55; 95% confidence interval, 1.202.01). Conclusion Factors leading to preeclampsia may shape susceptibility to metabolic or respiratory diseases in the offspring but a programming effect on respiratory diseases induced by preeclampsia cannot be ruled out. © 2011 Mosby, Inc.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/117390