Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
McLaughlin, RL
Schijven, D
Van Rheenen, W
Van Eijk, KR
O'Brien, M
Kahn, RS
Ophoff, RA
Goris, A
Bradley, DG
Al-Chalabi, A
Van Den Berg, LH
Luykx, JJ
Hardiman, O
Veldink, JH
Shatunov, A
Dekker, AM
Diekstra, FP
Pulit, SL
Van Der Spek, RAA
Van Doormaal, PTC
Sproviero, W
Jones, AR
Nicholson, GA
Rowe, DB
Pamphlett, R
Kiernan, MC
Bauer, D
Kahlke, T
Williams, K
Eftimov, F
Fogh, I
Ticozzi, N
Lin, K
Millecamps, S
Salachas, F
Meininger, V
Carvalho, MD
Pinto, S
Mora, JS
Rojas-Garcyá, R
Polak, M
Chandran, S
Colville, S
Swingler, R
Morrison, KE
Shaw, PJ
Hardy, J
Orrell, RW
Pittman, A
Sidle, K
Fratta, P
Malaspina, A
Petri, S
Abdulla, S
Drepper, C
Sendtner, M
Meyer, T
Wiedau-Pazos, M
Lomen-Hoerth, C
Deerlin, VMV
Trojanowski, JQ
Elman, L
McCluskey, L
Basak, N
Meitinger, T
Lichtner, P
Blagojevic-Radivojkov, M
Andres, CR
Maurel, C
Bensimon, G
Landwehrmeyer, B
Brice, A
Payan, CAM
Saker-Delye, S
Durr, A
Wood, N
Tittmann, L
Lieb, W
Franke, A
Rietschel, M
Cichon, S
Nothen, MM
Amouyel, P
Tzourio, C
Dartigues, JF
Uitterlinden, AG
Rivadeneira, F
Estrada, K
Hofman, A
Curtis, C
Derkooi, AJV
De Visser, M
Weber, M
Shaw, CE
Smith, BN
Pansarasa, O
Cereda, C
Bo, RD
Comi, GP
D'Alfonso, S
- Publication Type:
- Journal Article
- Citation:
- Nature Communications, 2017, 8
- Issue Date:
- 2017-03-21
Open Access
Copyright Clearance Process
- Recently Added
- In Progress
- Open Access
This item is open access.
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | McLaughlin, RL | en_US |
dc.contributor.author | Schijven, D | en_US |
dc.contributor.author | Van Rheenen, W | en_US |
dc.contributor.author | Van Eijk, KR | en_US |
dc.contributor.author | O'Brien, M | en_US |
dc.contributor.author | Kahn, RS | en_US |
dc.contributor.author | Ophoff, RA | en_US |
dc.contributor.author | Goris, A | en_US |
dc.contributor.author | Bradley, DG | en_US |
dc.contributor.author | Al-Chalabi, A | en_US |
dc.contributor.author | Van Den Berg, LH | en_US |
dc.contributor.author | Luykx, JJ | en_US |
dc.contributor.author | Hardiman, O | en_US |
dc.contributor.author | Veldink, JH | en_US |
dc.contributor.author | Shatunov, A | en_US |
dc.contributor.author | Dekker, AM | en_US |
dc.contributor.author | Diekstra, FP | en_US |
dc.contributor.author | Pulit, SL | en_US |
dc.contributor.author | Van Der Spek, RAA | en_US |
dc.contributor.author | Van Doormaal, PTC | en_US |
dc.contributor.author | Sproviero, W | en_US |
dc.contributor.author | Jones, AR | en_US |
dc.contributor.author | Nicholson, GA | en_US |
dc.contributor.author | Rowe, DB | en_US |
dc.contributor.author | Pamphlett, R | en_US |
dc.contributor.author | Kiernan, MC | en_US |
dc.contributor.author | Bauer, D | en_US |
dc.contributor.author |
Kahlke, T https://orcid.org/0000-0002-9762-6573 |
en_US |
dc.contributor.author | Williams, K | en_US |
dc.contributor.author | Eftimov, F | en_US |
dc.contributor.author | Fogh, I | en_US |
dc.contributor.author | Ticozzi, N | en_US |
dc.contributor.author | Lin, K | en_US |
dc.contributor.author | Millecamps, S | en_US |
dc.contributor.author | Salachas, F | en_US |
dc.contributor.author | Meininger, V | en_US |
dc.contributor.author | Carvalho, MD | en_US |
dc.contributor.author | Pinto, S | en_US |
dc.contributor.author | Mora, JS | en_US |
dc.contributor.author | Rojas-Garcyá, R | en_US |
dc.contributor.author | Polak, M | en_US |
dc.contributor.author | Chandran, S | en_US |
dc.contributor.author | Colville, S | en_US |
dc.contributor.author | Swingler, R | en_US |
dc.contributor.author | Morrison, KE | en_US |
dc.contributor.author | Shaw, PJ | en_US |
dc.contributor.author | Hardy, J | en_US |
dc.contributor.author | Orrell, RW | en_US |
dc.contributor.author | Pittman, A | en_US |
dc.contributor.author | Sidle, K | en_US |
dc.contributor.author | Fratta, P | en_US |
dc.contributor.author | Malaspina, A | en_US |
dc.contributor.author | Petri, S | en_US |
dc.contributor.author | Abdulla, S | en_US |
dc.contributor.author | Drepper, C | en_US |
dc.contributor.author | Sendtner, M | en_US |
dc.contributor.author | Meyer, T | en_US |
dc.contributor.author | Wiedau-Pazos, M | en_US |
dc.contributor.author | Lomen-Hoerth, C | en_US |
dc.contributor.author | Deerlin, VMV | en_US |
dc.contributor.author | Trojanowski, JQ | en_US |
dc.contributor.author | Elman, L | en_US |
dc.contributor.author | McCluskey, L | en_US |
dc.contributor.author | Basak, N | en_US |
dc.contributor.author | Meitinger, T | en_US |
dc.contributor.author | Lichtner, P | en_US |
dc.contributor.author | Blagojevic-Radivojkov, M | en_US |
dc.contributor.author | Andres, CR | en_US |
dc.contributor.author | Maurel, C | en_US |
dc.contributor.author | Bensimon, G | en_US |
dc.contributor.author | Landwehrmeyer, B | en_US |
dc.contributor.author | Brice, A | en_US |
dc.contributor.author | Payan, CAM | en_US |
dc.contributor.author | Saker-Delye, S | en_US |
dc.contributor.author | Durr, A | en_US |
dc.contributor.author | Wood, N | en_US |
dc.contributor.author | Tittmann, L | en_US |
dc.contributor.author | Lieb, W | en_US |
dc.contributor.author | Franke, A | en_US |
dc.contributor.author | Rietschel, M | en_US |
dc.contributor.author | Cichon, S | en_US |
dc.contributor.author | Nothen, MM | en_US |
dc.contributor.author | Amouyel, P | en_US |
dc.contributor.author | Tzourio, C | en_US |
dc.contributor.author | Dartigues, JF | en_US |
dc.contributor.author | Uitterlinden, AG | en_US |
dc.contributor.author | Rivadeneira, F | en_US |
dc.contributor.author | Estrada, K | en_US |
dc.contributor.author | Hofman, A | en_US |
dc.contributor.author | Curtis, C | en_US |
dc.contributor.author | Derkooi, AJV | en_US |
dc.contributor.author | De Visser, M | en_US |
dc.contributor.author | Weber, M | en_US |
dc.contributor.author | Shaw, CE | en_US |
dc.contributor.author | Smith, BN | en_US |
dc.contributor.author | Pansarasa, O | en_US |
dc.contributor.author | Cereda, C | en_US |
dc.contributor.author | Bo, RD | en_US |
dc.contributor.author | Comi, GP | en_US |
dc.contributor.author | D'Alfonso, S | en_US |
dc.date.available | 2017-02-03 | en_US |
dc.date.issued | 2017-03-21 | en_US |
dc.identifier.citation | Nature Communications, 2017, 8 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/125642 | |
dc.description.abstract | © 2017 The Author(s). We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies. | en_US |
dc.relation.ispartof | Nature Communications | en_US |
dc.relation.isbasedon | 10.1038/ncomms14774 | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Amyotrophic Lateral Sclerosis | en_US |
dc.subject.mesh | Genetic Predisposition to Disease | en_US |
dc.subject.mesh | Linear Models | en_US |
dc.subject.mesh | Odds Ratio | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Cohort Studies | en_US |
dc.subject.mesh | Family | en_US |
dc.subject.mesh | Schizophrenia | en_US |
dc.subject.mesh | Comorbidity | en_US |
dc.subject.mesh | Multifactorial Inheritance | en_US |
dc.subject.mesh | Linkage Disequilibrium | en_US |
dc.subject.mesh | Polymorphism, Single Nucleotide | en_US |
dc.subject.mesh | European Continental Ancestry Group | en_US |
dc.subject.mesh | Genome-Wide Association Study | en_US |
dc.title | Genetic correlation between amyotrophic lateral sclerosis and schizophrenia | en_US |
dc.type | Journal Article | |
utslib.citation.volume | 8 | en_US |
utslib.for | 0604 Genetics | en_US |
utslib.for | 1117 Public Health and Health Services | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - C3 - Climate Change Cluster | |
utslib.copyright.status | open_access | |
pubs.publication-status | Published | en_US |
pubs.volume | 8 | en_US |
Abstract:
© 2017 The Author(s). We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.
Please use this identifier to cite or link to this item:
Download statistics for the last 12 months
Not enough data to produce graph