Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology
- Publication Type:
- Journal Article
- Citation:
- Respiratory Research, 2018, 19 (1)
- Issue Date:
- 2018-09-17
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Tonga, KO | en_US |
dc.contributor.author | King, GG | en_US |
dc.contributor.author | Farah, CS | en_US |
dc.contributor.author | Thamrin, C | en_US |
dc.contributor.author | Tang, FS | en_US |
dc.contributor.author |
Santos, J https://orcid.org/0000-0003-4067-220X |
en_US |
dc.contributor.author |
Sharma, P https://orcid.org/0000-0002-2904-2306 |
en_US |
dc.contributor.author |
Chapman, DG https://orcid.org/0000-0002-8211-1817 |
en_US |
dc.contributor.author |
Oliver, BG https://orcid.org/0000-0002-7122-9262 |
en_US |
dc.date.available | 2018-09-05 | en_US |
dc.date.issued | 2018-09-17 | en_US |
dc.identifier.citation | Respiratory Research, 2018, 19 (1) | en_US |
dc.identifier.issn | 1465-9921 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/128720 | |
dc.description.abstract | © 2018 The Author(s). There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled corticosteroids (ICS). We assessed lung function (spirometry, forced oscillation technique (FOT)), lung elastic recoil and airway inflammation using bronchoalveolar lavage (BAL) in non-smoking adult asthmatics with FAO, following 2 months treatment with high-dose ICS/long-acting beta-agonist. Subjects demonstrated moderate FAO, abnormal FOT indices and loss of lung elastic recoil. This cross-sectional study showed a lack of a relationship between BAL neutrophils, eosinophils, inflammatory cytokines and lung function impairment. Other inflammatory pathways or the effect of inflammation on lung function over time may explain FAO development. | en_US |
dc.relation | http://purl.org/au-research/grants/nhmrc/APP1026880 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/APP1110368 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/APP1104704 | |
dc.relation.ispartof | Respiratory Research | en_US |
dc.relation.isbasedon | 10.1186/s12931-018-0880-2 | en_US |
dc.subject.classification | Respiratory System | en_US |
dc.subject.mesh | Bronchoalveolar Lavage Fluid | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Asthma | en_US |
dc.subject.mesh | Pulmonary Disease, Chronic Obstructive | en_US |
dc.subject.mesh | Inflammation | en_US |
dc.subject.mesh | Adrenal Cortex Hormones | en_US |
dc.subject.mesh | Respiratory Function Tests | en_US |
dc.subject.mesh | Forced Expiratory Volume | en_US |
dc.subject.mesh | Spirometry | en_US |
dc.subject.mesh | Cohort Studies | en_US |
dc.subject.mesh | Prospective Studies | en_US |
dc.subject.mesh | Cross-Sectional Studies | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Non-Smokers | en_US |
dc.title | Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology | en_US |
dc.type | Journal Article | |
utslib.citation.volume | 1 | en_US |
utslib.citation.volume | 19 | en_US |
utslib.for | 1102 Cardiorespiratory Medicine and Haematology | en_US |
utslib.for | 1103 Clinical Sciences | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
utslib.copyright.status | open_access | |
pubs.issue | 1 | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 19 | en_US |
Abstract:
© 2018 The Author(s). There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled corticosteroids (ICS). We assessed lung function (spirometry, forced oscillation technique (FOT)), lung elastic recoil and airway inflammation using bronchoalveolar lavage (BAL) in non-smoking adult asthmatics with FAO, following 2 months treatment with high-dose ICS/long-acting beta-agonist. Subjects demonstrated moderate FAO, abnormal FOT indices and loss of lung elastic recoil. This cross-sectional study showed a lack of a relationship between BAL neutrophils, eosinophils, inflammatory cytokines and lung function impairment. Other inflammatory pathways or the effect of inflammation on lung function over time may explain FAO development.
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