Pulmonary-intestinal cross-talk in mucosal inflammatory disease

Keely, S; Talley, NJ; Hansbro, PM

Pulmonary-intestinal cross-talk in mucosal inflammatory disease

Keely, S Talley, NJ Hansbro, PM

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Publication Type:: Journal Article
Citation:: Mucosal Immunology, 2012, 5 (1), pp. 7 - 18
Issue Date:: 2012-01-01

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Field	Value	Language
dc.contributor.author	Keely, S	en_US
dc.contributor.author	Talley, NJ	en_US
dc.contributor.author	Hansbro, PM https://orcid.org/0000-0002-4741-3035	en_US
dc.date.issued	2012-01-01	en_US
dc.identifier.citation	Mucosal Immunology, 2012, 5 (1), pp. 7 - 18	en_US
dc.identifier.issn	1933-0219	en_US
dc.identifier.uri	http://hdl.handle.net/10453/128838
dc.description.abstract	Chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBDs) are chronic inflammatory diseases of mucosal tissues that affect the respiratory and gastrointestinal tracts, respectively. They share many similarities in epidemiological and clinical characteristics, as well as in inflammatory pathologies. Importantly, both conditions are accompanied by systemic comorbidities that are largely overlooked in both basic and clinical research. Therefore, consideration of these complications may maximize the efficacy of prevention and treatment approaches. Here, we examine both the intestinal involvement in COPD and the pulmonary manifestations of IBD. We also review the evidence for inflammatory organ cross-talk that may drive these associations, and discuss the current frontiers of research into these issues.	en_US
dc.relation.ispartof	Mucosal Immunology	en_US
dc.relation.isbasedon	10.1038/mi.2011.55	en_US
dc.subject.classification	Immunology	en_US
dc.subject.mesh	Intestines	en_US
dc.subject.mesh	Lung	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Inflammatory Bowel Diseases	en_US
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive	en_US
dc.subject.mesh	Inflammation	en_US
dc.subject.mesh	Comorbidity	en_US
dc.subject.mesh	Cell Communication	en_US
dc.subject.mesh	Immunity, Mucosal	en_US
dc.title	Pulmonary-intestinal cross-talk in mucosal inflammatory disease	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	5	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	5	en_US

Abstract:

Chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBDs) are chronic inflammatory diseases of mucosal tissues that affect the respiratory and gastrointestinal tracts, respectively. They share many similarities in epidemiological and clinical characteristics, as well as in inflammatory pathologies. Importantly, both conditions are accompanied by systemic comorbidities that are largely overlooked in both basic and clinical research. Therefore, consideration of these complications may maximize the efficacy of prevention and treatment approaches. Here, we examine both the intestinal involvement in COPD and the pulmonary manifestations of IBD. We also review the evidence for inflammatory organ cross-talk that may drive these associations, and discuss the current frontiers of research into these issues.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/128838