Pulmonary-intestinal cross-talk in mucosal inflammatory disease

Publication Type:
Journal Article
Citation:
Mucosal Immunology, 2012, 5 (1), pp. 7 - 18
Issue Date:
2012-01-01
Metrics:
Full metadata record
Files in This Item:
Filename Description Size
Pulmonary-intestinal cross-talk in mucosal inflammatory disease.pdfPublished Version408.62 kB
Adobe PDF
Chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBDs) are chronic inflammatory diseases of mucosal tissues that affect the respiratory and gastrointestinal tracts, respectively. They share many similarities in epidemiological and clinical characteristics, as well as in inflammatory pathologies. Importantly, both conditions are accompanied by systemic comorbidities that are largely overlooked in both basic and clinical research. Therefore, consideration of these complications may maximize the efficacy of prevention and treatment approaches. Here, we examine both the intestinal involvement in COPD and the pulmonary manifestations of IBD. We also review the evidence for inflammatory organ cross-talk that may drive these associations, and discuss the current frontiers of research into these issues.
Please use this identifier to cite or link to this item: