Synthesis of 2′-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities

Mbere-Nguyen, U; Ung, AT; Pyne, SG

Synthesis of 2′-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities

Mbere-Nguyen, U Ung, AT

Pyne, SG

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Publication Type:: Journal Article
Citation:: Tetrahedron, 2010, 66 (23), pp. 4133 - 4143
Issue Date:: 2010-06-05

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Field	Value	Language
dc.contributor.author	Mbere-Nguyen, U	en_US
dc.contributor.author	Ung, AT https://orcid.org/0000-0002-5665-0702	en_US
dc.contributor.author	Pyne, SG	en_US
dc.date.issued	2010-06-05	en_US
dc.identifier.citation	Tetrahedron, 2010, 66 (23), pp. 4133 - 4143	en_US
dc.identifier.issn	0040-4020	en_US
dc.identifier.uri	http://hdl.handle.net/10453/13097
dc.description.abstract	Novel 2′-aminoalkyl-1-benzylisoquinoline compounds and medium size ring analogues have been prepared using reductive alkylation methods. Four of these analogues were tested for biological activity across 48 different CNS receptors and were showed to have binding activities at the mu opiod receptor. Crown Copyright © 2010.	en_US
dc.relation.ispartof	Tetrahedron	en_US
dc.relation.isbasedon	10.1016/j.tet.2010.03.110	en_US
dc.subject.classification	Organic Chemistry	en_US
dc.title	Synthesis of 2′-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities	en_US
dc.type	Journal Article
utslib.citation.volume	23	en_US
utslib.citation.volume	66	en_US
utslib.for	0305 Organic Chemistry	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
utslib.copyright.status	closed_access
pubs.issue	23	en_US
pubs.publication-status	Published	en_US
pubs.volume	66	en_US

Abstract:

Novel 2′-aminoalkyl-1-benzylisoquinoline compounds and medium size ring analogues have been prepared using reductive alkylation methods. Four of these analogues were tested for biological activity across 48 different CNS receptors and were showed to have binding activities at the mu opiod receptor. Crown Copyright © 2010.

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http://hdl.handle.net/10453/13097