Gold nanoparticles: New routes across old boundaries

Kumari, Y; Kaur, G; Kumar, R; Singh, SK; Gulati, M; Khursheed, R; Clarisse, A; Gowthamarajan, K; Karri, VVSNR; Mahalingam, R; Ghosh, D; Awasthi, A; Yadav, AK; Kapoor, B; Singh, PK; Dua, K; Porwal, O

Gold nanoparticles: New routes across old boundaries

Kumari, Y Kaur, G Kumar, R Singh, SK Gulati, M Khursheed, R Clarisse, A Gowthamarajan, K Karri, VVSNR Mahalingam, R Ghosh, D Awasthi, A Yadav, AK Kapoor, B Singh, PK Dua, K

Porwal, O

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Publication Type:: Journal Article
Citation:: Advances in Colloid and Interface Science, 2019, 274
Issue Date:: 2019-12-01

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Field	Value	Language
dc.contributor.author	Kumari, Y	en_US
dc.contributor.author	Kaur, G	en_US
dc.contributor.author	Kumar, R	en_US
dc.contributor.author	Singh, SK	en_US
dc.contributor.author	Gulati, M	en_US
dc.contributor.author	Khursheed, R	en_US
dc.contributor.author	Clarisse, A	en_US
dc.contributor.author	Gowthamarajan, K	en_US
dc.contributor.author	Karri, VVSNR	en_US
dc.contributor.author	Mahalingam, R	en_US
dc.contributor.author	Ghosh, D	en_US
dc.contributor.author	Awasthi, A	en_US
dc.contributor.author	Yadav, AK	en_US
dc.contributor.author	Kapoor, B	en_US
dc.contributor.author	Singh, PK	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.contributor.author	Porwal, O	en_US
dc.date.available	2019-09-17	en_US
dc.date.issued	2019-12-01	en_US
dc.identifier.citation	Advances in Colloid and Interface Science, 2019, 274	en_US
dc.identifier.issn	0001-8686	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136948
dc.description.abstract	© 2019 Elsevier B.V. In recent years, gold nanoparticles have emerged as unique non-invasive drug carriers for targeting drugs to their site of action. Their site specificity has helped in increasing drugs' efficacy at lower dose as well as reduction in their side effects. Moreover, their excellent optical properties and small size offer their utilization as diagnostic tools to diagnose tumors as well as other diseases. This review focuses on various approaches that have been used in last several years for preparation of gold nanoparticles, their characterization techniques and theranostic applications. Their toxicity related aspects are also highlighted. Gold nanoparticles are useful as theranostic agents, owing to their small size, biocompatible nature, size dependent physical, chemical and optical properties etc. However, the challenges associated with these nanoparticles such as scale up, cost, low drug payload, toxicity and stability have been the major impediments in their commercialization. The review looks into all these critical issues and identifies the possibilities to overcome these challenges for successful positioning of metallic nanoparticles in market.	en_US
dc.relation.ispartof	Advances in Colloid and Interface Science	en_US
dc.relation.isbasedon	10.1016/j.cis.2019.102037	en_US
dc.subject.classification	Chemical Physics	en_US
dc.title	Gold nanoparticles: New routes across old boundaries	en_US
dc.type	Journal Article
utslib.citation.volume	274	en_US
utslib.for	1007 Nanotechnology	en_US
utslib.for	1117 Public Health and Health Services	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	09 Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	274	en_US

Abstract:

© 2019 Elsevier B.V. In recent years, gold nanoparticles have emerged as unique non-invasive drug carriers for targeting drugs to their site of action. Their site specificity has helped in increasing drugs' efficacy at lower dose as well as reduction in their side effects. Moreover, their excellent optical properties and small size offer their utilization as diagnostic tools to diagnose tumors as well as other diseases. This review focuses on various approaches that have been used in last several years for preparation of gold nanoparticles, their characterization techniques and theranostic applications. Their toxicity related aspects are also highlighted. Gold nanoparticles are useful as theranostic agents, owing to their small size, biocompatible nature, size dependent physical, chemical and optical properties etc. However, the challenges associated with these nanoparticles such as scale up, cost, low drug payload, toxicity and stability have been the major impediments in their commercialization. The review looks into all these critical issues and identifies the possibilities to overcome these challenges for successful positioning of metallic nanoparticles in market.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/136948