Toward best practice methods for delirium biomarker studies: An international modified Delphi study.

Amgarth-Duff, I; Hosie, A; Caplan, G; Agar, M

Toward best practice methods for delirium biomarker studies: An international modified Delphi study.

Amgarth-Duff, I Hosie, A

Caplan, G Agar, M

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: International journal of geriatric psychiatry, 2020, 35, (7), pp. 737-748
Issue Date:: 2020-07

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Field	Value	Language
dc.contributor.author	Amgarth-Duff, I
dc.contributor.author	Hosie, A https://orcid.org/0000-0003-1674-2124
dc.contributor.author	Caplan, G
dc.contributor.author	Agar, M https://orcid.org/0000-0002-6756-6119
dc.date.accessioned	2020-10-08T05:33:13Z
dc.date.available	2020-02-25
dc.date.available	2020-10-08T05:33:13Z
dc.date.issued	2020-07
dc.identifier.citation	International journal of geriatric psychiatry, 2020, 35, (7), pp. 737-748
dc.identifier.issn	0885-6230
dc.identifier.issn	1099-1166
dc.identifier.uri	http://hdl.handle.net/10453/143154
dc.description.abstract	BACKGROUND:Delirium is a serious and distressing neurocognitive condition common in people with advanced illness. The understanding of delirium pathophysiology is limited and largely hypothetical. To accelerate empirical understanding of delirium pathophysiology, robust scientific methods for conducting and reporting delirium biomarker studies are urgently needed. The aim of this study was to develop international consensus on the core elements of high-quality delirium biomarker studies. METHODS:A three-round modified Delphi survey was conducted from February to August 2019. Participants were international researchers experienced in conducting delirium studies from a range of settings (hospital, university, research centres). Round one commenced with open-ended questions developed from results from a prior systematic review and the REMARK (REporting recommendations for tumour MARKer prognostic studies) checklist. Responses were qualitatively analysed, and closed statements were developed. Participants then ranked the importance of these statements using a 5-point Likert scale in rounds 2 and 3. A priori consensus was defined as ≥70% participant agreement. Descriptive statistics for each item were computed including the mean Likert scores, SD and median participant scores. RESULTS:Twenty-eight participants completed survey round one, 16 completed round two and 19 completed the final round. Consensus was achieved for a total of 60 items. CONCLUSION:The Delphi survey identified items that expert researchers agreed were important in the conduct of delirium biomarker studies. These reporting items provide a strong platform for improved methodological quality and opportunities to synthesise future delirium biomarker studies.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation.ispartof	International journal of geriatric psychiatry
dc.relation.isbasedon	10.1002/gps.5292
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1701 Psychology, 1702 Cognitive Sciences
dc.subject.classification	Geriatrics
dc.title	Toward best practice methods for delirium biomarker studies: An international modified Delphi study.
dc.type	Journal Article
utslib.citation.volume	35
utslib.location.activity	England
utslib.for	1103 Clinical Sciences
utslib.for	1701 Psychology
utslib.for	1702 Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-10-08T05:33:06Z
pubs.issue	7
pubs.publication-status	Published
pubs.volume	35
utslib.citation.issue	7

Abstract:

BACKGROUND:Delirium is a serious and distressing neurocognitive condition common in people with advanced illness. The understanding of delirium pathophysiology is limited and largely hypothetical. To accelerate empirical understanding of delirium pathophysiology, robust scientific methods for conducting and reporting delirium biomarker studies are urgently needed. The aim of this study was to develop international consensus on the core elements of high-quality delirium biomarker studies. METHODS:A three-round modified Delphi survey was conducted from February to August 2019. Participants were international researchers experienced in conducting delirium studies from a range of settings (hospital, university, research centres). Round one commenced with open-ended questions developed from results from a prior systematic review and the REMARK (REporting recommendations for tumour MARKer prognostic studies) checklist. Responses were qualitatively analysed, and closed statements were developed. Participants then ranked the importance of these statements using a 5-point Likert scale in rounds 2 and 3. A priori consensus was defined as ≥70% participant agreement. Descriptive statistics for each item were computed including the mean Likert scores, SD and median participant scores. RESULTS:Twenty-eight participants completed survey round one, 16 completed round two and 19 completed the final round. Consensus was achieved for a total of 60 items. CONCLUSION:The Delphi survey identified items that expert researchers agreed were important in the conduct of delirium biomarker studies. These reporting items provide a strong platform for improved methodological quality and opportunities to synthesise future delirium biomarker studies.

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http://hdl.handle.net/10453/143154