Design of endoperoxides with anti-Candida activity
- Publication Type:
- Journal Article
- Bioorganic and Medicinal Chemistry, 2007, 15 (1), pp. 36 - 42
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Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. © 2006 Elsevier Ltd. All rights reserved.
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