Design of endoperoxides with anti-Candida activity

Avery, TD; Macreadie, PI; Greatrex, BW; Robinson, TV; Taylor, DK; Macreadie, IG

Design of endoperoxides with anti-Candida activity

Avery, TD Macreadie, PI

Greatrex, BW Robinson, TV Taylor, DK Macreadie, IG

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Publication Type:: Journal Article
Citation:: Bioorganic and Medicinal Chemistry, 2007, 15 (1), pp. 36 - 42
Issue Date:: 2007-01-01

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Field	Value	Language
dc.contributor.author	Avery, TD	en_US
dc.contributor.author	Macreadie, PI https://orcid.org/0000-0001-7362-0882	en_US
dc.contributor.author	Greatrex, BW	en_US
dc.contributor.author	Robinson, TV	en_US
dc.contributor.author	Taylor, DK	en_US
dc.contributor.author	Macreadie, IG	en_US
dc.date.available	2006-10-11	en_US
dc.date.issued	2007-01-01	en_US
dc.identifier.citation	Bioorganic and Medicinal Chemistry, 2007, 15 (1), pp. 36 - 42	en_US
dc.identifier.issn	0968-0896	en_US
dc.identifier.uri	http://hdl.handle.net/10453/14638
dc.description.abstract	Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. © 2006 Elsevier Ltd. All rights reserved.	en_US
dc.relation.ispartof	Bioorganic and Medicinal Chemistry	en_US
dc.relation.isbasedon	10.1016/j.bmc.2006.10.021	en_US
dc.subject.classification	Medicinal & Biomolecular Chemistry	en_US
dc.subject.mesh	Erythrocytes	en_US
dc.subject.mesh	CHO Cells	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Candida albicans	en_US
dc.subject.mesh	Peroxides	en_US
dc.subject.mesh	Antifungal Agents	en_US
dc.subject.mesh	Microbial Sensitivity Tests	en_US
dc.subject.mesh	Cell Proliferation	en_US
dc.subject.mesh	Molecular Conformation	en_US
dc.subject.mesh	Structure-Activity Relationship	en_US
dc.subject.mesh	Drug Design	en_US
dc.subject.mesh	Stereoisomerism	en_US
dc.subject.mesh	Cricetinae	en_US
dc.title	Design of endoperoxides with anti-Candida activity	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	15	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	0305 Organic Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	15	en_US

Abstract:

Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. © 2006 Elsevier Ltd. All rights reserved.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/14638