School of Biomedical Engineering

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Factors associated with fragility fractures in type 2 diabetes: An analysis of the randomised controlled Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.

Sheu, A O'Connell, RL Jenkins, AJ Tran, T Drury, PL Sullivan, DR Li, L Colman, P O'Brien, R Kesäniemi, YA Center, JR White, CP Keech, AC

AIMS: Fracture risk is elevated in some type 2 diabetes patients. Bone fragility may be associated with more clinically severe type 2 diabetes, although prospective studies are lacking. It is unkno...

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The evaluation of an osteoporosis medication management service in community pharmacy, a cohort study.

Phuong, J Manon, S Moles, R Mason, D Vleeskens, C Rezae, F White, C Center, J Carter, S

Background: Effective treatment of osteoporosis is hindered by poor adherence and lack of persistence with medical therapy. Interventions can be designed to elicit and address patients' concerns ab...

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Towards understanding Trans-cleavage of natural and synthetic nucleic acids by Cas12a for sensitive CRISPR biosensing

Deng, F Sang, R Li, Y Yang, D Mckinnirey, F Deng, W Goldys, EM

CRISPR/Cas systems have been widely utilized for the development of biosensing platforms for precision molecular diagnostics. Their remarkable biosensing performance critically depends on the effic...

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XGBoost-SHAP-based interpretable diagnostic framework for knee osteoarthritis: a population-based retrospective cohort study.

Fan, Z Song, W Ke, Y Jia, L Li, S Li, JJ Zhang, Y Lin, J Wang, B

OBJECTIVE: To use routine demographic and clinical data to develop an interpretable individual-level machine learning (ML) model to diagnose knee osteoarthritis (KOA) and to identify highly ranked ...

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Targeted polymer lipid hybrid nanoparticles for in-vitro siRNA therapy in triple-negative breast cancer

Mehta, M Bui, TA Care, A Deng, W

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, characterised by a lack of hormone receptors and HER2 expression, resulting in limited treatment options and poor pat...

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Retinal health screening using artificial intelligence with digital fundus images: A review of the last decade (2012-2023)

Islam, S Deo, RC Barua, PD Soar, J Yu, P Rajendra Acharya, U

Prolonged diabetic retinopathy (DR), glaucoma, and age-related macular degeneration (AMD) may lead to vision loss. Hence, early detection and treatment are crucial to prevent irreversible vision lo...

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Outcomes of lumen apposing metal stent placement in patients with surgically altered anatomy: Multicenter international experience.

Mangiavillano, B Ramai, D Kahaleh, M Tyberg, A Shahid, H Sarkar, A Samanta, J Dhar, J Bronswijk, M Van der Merwe, S Kouanda, A Ji, H Dai, S-C Deprez, P Vargas-Madrigal, J Vanella, G Roberto, L Arcidiacono, PG Robles-Medranda, C Alcivar Vasquez, J Arevalo-Mora, M Fugazza, A Ko, C Morris, J Lisotti, A Fusaroli, P Dhaliwal, A Mutignani, M Forti, E Cottone, I Larghi, A Rizzatti, G Galasso, D Barbera, C Di Matteo, FM Stigliano, S Binda, C Fabbri, C Pham, KD-C Di Mitri, R Amata, M Crinó, SF Ofosu, A De Luca, L Al-Lehibi, A Auriemma, F Paduano, D Calabrese, F Gentile, C Hassan, C Repici, A Facciorusso, A

Background and study aims Although outcomes of lumen-apposing metal stents (LAMS) placement in native anatomy have been reported, data on LAMS placement in surgically altered anatomy (SAA) are spar...

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Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis.

Cheung, BB Mittra, R Murray, J Wang, Q Seneviratne, JA Raipuria, M Wong, IPL Restuccia, D Gifford, A Salib, A Sutton, S Huang, L Ferdowsi, PV Tsang, J Sekyere, E Mayoh, C Luo, L Brown, DL Stow, JL Zhu, S Young, RJ Solomon, BJ Chappaz, S Kile, B Kueh, A Herold, MJ Hilton, DJ Liu, T Norris, MD Haber, M Carter, DR Parker, MW Marshall, GM

MYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neurobl...

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A randomised controlled phase II trial to examine the feasibility of using hyper-oxygenated fatty acids (HOFA) to prevent facial pressure injuries from medical devices among adults admitted to intensive care-A research protocol.

Hunt, L Ingleman, J Brennen, K Armstrong, K Hazell, M Keith, N Bickford, B Sanchez, D Khalil, S Geering, S Sigdel, SA Skaria, S Prabhakaran, S Lynch, J Alexandrou, E Drury, P Tran, T Frost, SA

One in three patients admitted to intensive care will sustain a pressure injury (PI) from a medical device. These injuries are painful and when on the face, head or neck they can result in permanen...

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Lobish: Symbolic Language for Interpreting Electroencephalogram Signals in Language Detection Using Channel-Based Transformation and Pattern.

Tuncer, T Dogan, S Tasci, I Baygin, M Barua, PD Acharya, UR

Electroencephalogram (EEG) signals contain information about the brain's state as they reflect the brain's functioning. However, the manual interpretation of EEG signals is tedious and time-consumi...

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