School of Biomedical Engineering

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Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.

Kapellos, TS Baßler, K Fujii, W Nalkurthi, C Schaar, AC Bonaguro, L Pecht, T Galvao, I Agrawal, S Saglam, A Dudkin, E Frishberg, A de Domenico, E Horne, A Donovan, C Kim, RY Gallego-Ortega, D Gillett, TE Ansari, M Schulte-Schrepping, J Offermann, N Antignano, I Sivri, B Lu, W Eapen, MS van Uelft, M Osei-Sarpong, C van den Berge, M Donker, HC Groen, HJM Sohal, SS Klein, J Schreiber, T Feißt, A Yildirim, AÖ Schiller, HB Nawijn, MC Becker, M Händler, K Beyer, M Capasso, M Ulas, T Hasenauer, J Pizarro, C Theis, FJ Hansbro, PM Skowasch, D Schultze, JL

Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defin...

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Prevalence Of Radiographic Osteoarthritis Of The Knee And Its Relationship To Self-Reported Pain

Ho-pham, L Lai, T Mai, L Doan, M Pham, H Nguyen, T

Background and Aim: Osteoarthritis (OA) of the knee is one of the most common skeletal disorders, yet little data are available in Asian populations. We sought to assess the prevalence and pattern ...

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Prognostic performance of the Rapid Emergency Medicine Score (REMS) and Worthing Physiological Scoring system (WPS) in emergency department.

Ha, DT Dang, TQ Tran, NV Vo, NY Nguyen, ND Nguyen, TV

BACKGROUND: The Rapid Emergency Medicine Score (REMS) and Worthing Physiological Scoring system (WPS) have been developed for predicting in-hospital mortality in nonsurgical emergency department (E...

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'Skeletal Age' for mapping the impact of fracture on mortality.

Tran, T Ho-Le, T Bliuc, D Abrahamsen, B Hansen, L Vestergaard, P Center, JR Nguyen, TV

BACKGROUND: Fragility fracture is associated with an increased risk of mortality, but mortality is not part of doctor-patient communication. Here, we introduce a new concept called 'Skeletal Age' a...

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Evaluating the safety and efficacy of mesenchymal stem cell-derived exosomes for treatment of refractory perianal fistula in IBD patients: clinical trial phase I.

Nazari, H Alborzi, F Heirani-Tabasi, A Hadizadeh, A Asbagh, RA Behboudi, B Fazeli, MS Rahimi, M Keramati, MR Keshvari, A Kazemeini, A Soleimani, M Ahmadi Tafti, SM

BACKGROUND: Exosome administration is a novel medical approach that promises excellent immunomodulatory properties without the conventional side effects of current antitumor necrosis factor drugs a...

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DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicine.

Fatemi, N Tierling, S Es, HA Varkiani, M Mojarad, EN Aghdaei, HA Walter, J Totonchi, M

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is attributed to gradual long-term accumulation of both genetic and epigenetic changes. To reduce the mortality ra...

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Clinical Applications of Circulating Tumour Cells and Circulating Tumour DNA in Non-Small Cell Lung Cancer-An Update.

Kapeleris, J Ebrahimi Warkiani, M Kulasinghe, A Vela, I Kenny, L Ladwa, R O'Byrne, K Punyadeera, C

Despite efforts to improve earlier diagnosis of non-small cell lung cancer (NSCLC), most patients present with advanced stage disease, which is often associated with poor survival outcomes with onl...

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Liver Isolation Oxaliplatin (LIOX): Long Term Survival from a New Locoregional Technique for Chemorefractory Patients with Colorectal Liver Metastases

Khin, NY DeSilva, M Clarke, S Pavlakis, N Rogan, CM Ho-Shon, K Lane, RJ

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HNF4α is possibly the missing link between epithelial–mesenchymal transition and Warburg effect during hepatocarcinogenesis

Shokouhian, B Negahdari, B Heydari, Z Totonchi, M Es, HA Piryaei, A Mostafavi, E Vosough, M

Hepatocellular carcinoma (HCC) is a heterogeneous, late-diagnosed, and highly recurrent malignancy that often affects the whole body's metabolism. Finding certain theranostic molecules that can add...

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Advanced models for respiratory disease and drug studies.

Shrestha, J Paudel, KR Nazari, H Dharwal, V Bazaz, SR Johansen, MD Dua, K Hansbro, PM Warkiani, ME

The global burden of respiratory diseases is enormous, with many millions of people suffering and dying prematurely every year. The global COVID-19 pandemic witnessed recently, along with increased...

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