RNAi: Nature abhors a double-strand

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Journal Article
Current Opinion in Genetics and Development, 2002, 12 (2), pp. 225 - 232
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In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.
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