Cloning and analysis of a Trichinella pseudospiralis muscle larva secreted serine protease gene.

Publisher:
Elsevier Inc
Publication Type:
Journal Article
Citation:
Veterinary Parasitology, 2009, 159 (3-4), pp. 268 - 271
Issue Date:
2009-01
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Nematode parasites of the genus Trichinella are intracellular and distinct life cycle stages invade intestinal epithelial and skeletal muscle cells. Within the genus, Trichinella spiralis and Trichinella pseudospiralis exhibit species-specific differences with respect to hostparasite complex formation and host immune modulation. Parasite excretory-secretory (ES) proteins play important roles at the host-parasite interface and are thought to underpin these differences in biology. Serine proteases are among the most abundant group of T. spiralis ES proteins and multiple isoforms of themuscle larvae-specific TspSP-1 serine protease have been identified. Recently, a similar protein (TppSP-1) in T. pseudospiralis muscle larvae was identified. Here we report the cloning and characterisation of the full-length transcript of TppSP-1 and present comparative data between TspSP- 1 and TppSP-1.
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