Exploring role of polysaccharides present in Ganoderma lucidium extract powder and probiotics as solid carriers in development of liquisolid formulation loaded with quercetin: A novel study.

Khursheed, R; Singh, SK; Gulati, M; Wadhwa, S; Kapoor, B; Pandey, NK; Chellappan, DK; Gupta, G; Jha, NK; Dua, K; Kapoor, DN; Karri, VVSR; Pattanayak, P; Sharni, A; Mondal, S

Exploring role of polysaccharides present in Ganoderma lucidium extract powder and probiotics as solid carriers in development of liquisolid formulation loaded with quercetin: A novel study.

Khursheed, R Singh, SK Gulati, M Wadhwa, S Kapoor, B Pandey, NK Chellappan, DK Gupta, G Jha, NK Dua, K

Kapoor, DN Karri, VVSR Pattanayak, P Sharni, A Mondal, S

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: International journal of biological macromolecules, 2021
Issue Date:: 2021-05-17

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Field	Value	Language
dc.contributor.author	Khursheed, R
dc.contributor.author	Singh, SK
dc.contributor.author	Gulati, M
dc.contributor.author	Wadhwa, S
dc.contributor.author	Kapoor, B
dc.contributor.author	Pandey, NK
dc.contributor.author	Chellappan, DK
dc.contributor.author	Gupta, G
dc.contributor.author	Jha, NK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Kapoor, DN
dc.contributor.author	Karri, VVSR
dc.contributor.author	Pattanayak, P
dc.contributor.author	Sharni, A
dc.contributor.author	Mondal, S
dc.date.accessioned	2021-05-26T22:42:33Z
dc.date.available	2021-05-10
dc.date.available	2021-05-26T22:42:33Z
dc.date.issued	2021-05-17
dc.identifier.citation	International journal of biological macromolecules, 2021
dc.identifier.issn	0141-8130
dc.identifier.issn	1879-0003
dc.identifier.uri	http://hdl.handle.net/10453/149248
dc.description.abstract	Ganoderma lucidium extract powder (GLEP) contains various polysaccharides which are well known for their antioxidant and anti-inflammatory actions. Probiotics (PB) are well-established for providing a plethora of health benefits. Hence, use of mushroom polysaccharides and probiotics as carriers to solidify liquisolid formulation is anticipated to function as functional excipients i.e. as adsorbent that may provide therapeutic benefits. Quercetin (QUR) has been used as model lipophilic drug in this study. QUR loaded liquisolid compacts (LSCs) were formulated using Tween 80 as solvent. These were further solidified using a combination of PB and GLEP as carriers. Aerosil-200 (A-200) was used as coating agent. The formulation exhibited very good flow characteristics. Dissolution rate of raw QUR was found to be less than 10% in 60 min while in case of QUR loaded LSCs, more than 90% drug release was observed within 5 min. Absence of crystalline peaks of QUR in the DSC and PXRD reports of LSCs and their porous appearance in SEM micrographs indicate that QUR was successfully incorporated in the LSCs. The developed formulation was found to be stable on storage under accelerated stability conditions.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	International journal of biological macromolecules
dc.relation.isbasedon	10.1016/j.ijbiomac.2021.05.064
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology
dc.subject.classification	Polymers
dc.title	Exploring role of polysaccharides present in Ganoderma lucidium extract powder and probiotics as solid carriers in development of liquisolid formulation loaded with quercetin: A novel study.
dc.type	Journal Article
utslib.location.activity	Netherlands
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2021-05-26T22:42:31Z
pubs.publication-status	Published

Abstract:

Ganoderma lucidium extract powder (GLEP) contains various polysaccharides which are well known for their antioxidant and anti-inflammatory actions. Probiotics (PB) are well-established for providing a plethora of health benefits. Hence, use of mushroom polysaccharides and probiotics as carriers to solidify liquisolid formulation is anticipated to function as functional excipients i.e. as adsorbent that may provide therapeutic benefits. Quercetin (QUR) has been used as model lipophilic drug in this study. QUR loaded liquisolid compacts (LSCs) were formulated using Tween 80 as solvent. These were further solidified using a combination of PB and GLEP as carriers. Aerosil-200 (A-200) was used as coating agent. The formulation exhibited very good flow characteristics. Dissolution rate of raw QUR was found to be less than 10% in 60 min while in case of QUR loaded LSCs, more than 90% drug release was observed within 5 min. Absence of crystalline peaks of QUR in the DSC and PXRD reports of LSCs and their porous appearance in SEM micrographs indicate that QUR was successfully incorporated in the LSCs. The developed formulation was found to be stable on storage under accelerated stability conditions.

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http://hdl.handle.net/10453/149248