Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics.

Thapa, R; Afzal, M; Goyal, A; Gupta, G; Bhat, AA; Almalki, WH; Kazmi, I; Alzarea, SI; Shahwan, M; Kukreti, N; Ali, H; Dureja, H; Kumar, P; Singh, TG; Kuppusamy, G; Singh, SK; Dua, K

Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics.

Thapa, R Afzal, M Goyal, A Gupta, G Bhat, AA Almalki, WH Kazmi, I Alzarea, SI Shahwan, M Kukreti, N Ali, H Dureja, H Kumar, P Singh, TG Kuppusamy, G Singh, SK Dua, K

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Life Sci, 2024, 345, pp. 122613
Issue Date:: 2024-04-04

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Field	Value	Language
dc.contributor.author	Thapa, R
dc.contributor.author	Afzal, M
dc.contributor.author	Goyal, A
dc.contributor.author	Gupta, G
dc.contributor.author	Bhat, AA
dc.contributor.author	Almalki, WH
dc.contributor.author	Kazmi, I
dc.contributor.author	Alzarea, SI
dc.contributor.author	Shahwan, M
dc.contributor.author	Kukreti, N
dc.contributor.author	Ali, H
dc.contributor.author	Dureja, H
dc.contributor.author	Kumar, P
dc.contributor.author	Singh, TG
dc.contributor.author	Kuppusamy, G
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2024-04-13T04:42:04Z
dc.date.available	2024-04-03
dc.date.available	2024-04-13T04:42:04Z
dc.date.issued	2024-04-04
dc.identifier.citation	Life Sci, 2024, 345, pp. 122613
dc.identifier.issn	0024-3205
dc.identifier.issn	1879-0631
dc.identifier.uri	http://hdl.handle.net/10453/177883
dc.description.abstract	Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a discouragingly low survival rate and few effective treatments. An important function of the EGFR signalling pathway in the development of GBM is to affect tumor proliferation, persistence, and treatment resistance. Advances in molecular biology in the last several years have shown how important ncRNAs are for controlling a wide range of biological activities, including cancer progression and development. NcRNAs have become important post-transcriptional regulators of gene expression, and they may affect the EGFR pathway by either directly targeting EGFR or by modifying important transcription factors and downstream signalling molecules. The EGFR pathway is aberrantly activated in response to the dysregulation of certain ncRNAs, which has been linked to GBM carcinogenesis, treatment resistance, and unfavourable patient outcomes. We review the literature on miRNAs, circRNAs and lncRNAs that are implicated in the regulation of EGFR signalling in GBM, discussing their mechanisms of action, interactions with the signalling pathway, and implications for GBM therapy. Furthermore, we explore the potential of ncRNA-based strategies to overcome resistance to EGFR-targeted therapies, including the use of ncRNA mimics or inhibitors to modulate the activity of key regulators within the pathway.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Life Sci
dc.relation.isbasedon	10.1016/j.lfs.2024.122613
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Pharmacology & Pharmacy
dc.subject.classification	3101 Biochemistry and cell biology
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.title	Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics.
dc.type	Journal Article
utslib.citation.volume	345
utslib.location.activity	Netherlands
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2024-04-13T04:42:01Z
pubs.publication-status	Published online
pubs.volume	345

Abstract:

Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a discouragingly low survival rate and few effective treatments. An important function of the EGFR signalling pathway in the development of GBM is to affect tumor proliferation, persistence, and treatment resistance. Advances in molecular biology in the last several years have shown how important ncRNAs are for controlling a wide range of biological activities, including cancer progression and development. NcRNAs have become important post-transcriptional regulators of gene expression, and they may affect the EGFR pathway by either directly targeting EGFR or by modifying important transcription factors and downstream signalling molecules. The EGFR pathway is aberrantly activated in response to the dysregulation of certain ncRNAs, which has been linked to GBM carcinogenesis, treatment resistance, and unfavourable patient outcomes. We review the literature on miRNAs, circRNAs and lncRNAs that are implicated in the regulation of EGFR signalling in GBM, discussing their mechanisms of action, interactions with the signalling pathway, and implications for GBM therapy. Furthermore, we explore the potential of ncRNA-based strategies to overcome resistance to EGFR-targeted therapies, including the use of ncRNA mimics or inhibitors to modulate the activity of key regulators within the pathway.

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http://hdl.handle.net/10453/177883