| Field |
Value |
Language |
|
dc.contributor.author |
Phillips, MJA |
|
|
dc.contributor.author |
Huston, WM |
|
|
dc.contributor.author |
McDonagh, AM |
|
|
dc.contributor.author |
Rawling, T
https://orcid.org/0000-0002-6624-6586
|
|
|
dc.date.accessioned |
2024-08-02T02:42:03Z |
|
|
dc.date.available |
2024-03-26 |
|
|
dc.date.available |
2024-08-02T02:42:03Z |
|
|
dc.date.issued |
2024-03-28 |
|
|
dc.identifier.citation |
Molecules, 2024, 29, (7), pp. 1519 |
|
|
dc.identifier.issn |
1420-3049 |
|
|
dc.identifier.issn |
1420-3049 |
|
|
dc.identifier.uri |
http://hdl.handle.net/10453/179994
|
|
|
dc.description.abstract |
4-Chloroisocoumarin compounds have broad inhibitory properties against serine proteases. Here, we show that selected 3-alkoxy-4-chloroisocoumarins preferentially inhibit the activity of the conserved serine protease High-temperature requirement A of Chlamydia trachomatis. The synthesis of a new series of isocoumarin-based scaffolds has been developed, and their anti-chlamydial properties were investigated. The structure of the alkoxy substituent was found to influence the potency of the compounds against High-temperature requirement A, and modifications to the C-7 position of the 3-alkoxy-4-chloroisocoumarin structure attenuate anti-chlamydial properties. |
|
|
dc.format |
Electronic |
|
|
dc.language |
eng |
|
|
dc.publisher |
MDPI |
|
|
dc.relation.ispartof |
Molecules |
|
|
dc.relation.isbasedon |
10.3390/molecules29071519 |
|
|
dc.rights |
info:eu-repo/semantics/openAccess |
|
|
dc.subject |
0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, 0307 Theoretical and Computational Chemistry |
|
|
dc.subject.classification |
Organic Chemistry |
|
|
dc.subject.classification |
3404 Medicinal and biomolecular chemistry |
|
|
dc.subject.classification |
3405 Organic chemistry |
|
|
dc.subject.mesh |
Protease Inhibitors |
|
|
dc.subject.mesh |
Chlamydia trachomatis |
|
|
dc.subject.mesh |
Enzyme Therapy |
|
|
dc.subject.mesh |
Isocoumarins |
|
|
dc.subject.mesh |
Serine Endopeptidases |
|
|
dc.subject.mesh |
Serine Proteases |
|
|
dc.subject.mesh |
Alcohols |
|
|
dc.subject.mesh |
Chlamydia trachomatis |
|
|
dc.subject.mesh |
Alcohols |
|
|
dc.subject.mesh |
Serine Endopeptidases |
|
|
dc.subject.mesh |
Protease Inhibitors |
|
|
dc.subject.mesh |
Isocoumarins |
|
|
dc.subject.mesh |
Serine Proteases |
|
|
dc.subject.mesh |
Enzyme Therapy |
|
|
dc.subject.mesh |
Protease Inhibitors |
|
|
dc.subject.mesh |
Chlamydia trachomatis |
|
|
dc.subject.mesh |
Enzyme Therapy |
|
|
dc.subject.mesh |
Isocoumarins |
|
|
dc.subject.mesh |
Serine Endopeptidases |
|
|
dc.subject.mesh |
Serine Proteases |
|
|
dc.subject.mesh |
Alcohols |
|
|
dc.title |
4-Chloroisocoumarins as Chlamydial Protease Inhibitors and Anti-Chlamydial Agents. |
|
|
dc.type |
Journal Article |
|
|
utslib.citation.volume |
29 |
|
|
utslib.location.activity |
Switzerland |
|
|
utslib.for |
0304 Medicinal and Biomolecular Chemistry |
|
|
utslib.for |
0305 Organic Chemistry |
|
|
utslib.for |
0307 Theoretical and Computational Chemistry |
|
|
pubs.organisational-group |
University of Technology Sydney |
|
|
pubs.organisational-group |
University of Technology Sydney/Faculty of Science |
|
|
pubs.organisational-group |
University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences |
|
|
pubs.organisational-group |
University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology |
|
|
utslib.copyright.status |
open_access |
* |
|
dc.rights.license |
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ |
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|
dc.date.updated |
2024-08-02T02:41:58Z |
|
|
pubs.issue |
7 |
|
|
pubs.publication-status |
Published online |
|
|
pubs.volume |
29 |
|
|
utslib.citation.issue |
7 |
|
