Synthesis and impurity profiling of MDMA prepared from commonly available starting materials

Publication Type:
Journal Article
Citation:
Forensic Science International, 2012, 223 (1-3), pp. 306 - 313
Issue Date:
2012-11-30
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2012001403OK.pdf1.04 MB
Adobe PDF
This work examines the synthesis of 3,4-methylenedioxy-N-methylamphetamine (MDMA) from common starting materials that may be utilised by clandestine laboratory operators. Piperonal was prepared from two common starting materials, piperine (from pepper) and vanillin (a common flavouring). Piperine was converted to piperonal by ozonolysis and oxidative cleavage with potassium permanganate and tetrahydrofuran. Vanillin was converted to piperonal by demethylation with pyridine and aluminium chloride followed by methylenation with dichloromethane. The resulting piperonal samples were converted via a commonly encountered route to MDMA. The impurities that indicate a particular route were identified and the feasibility of each method was also assessed. © 2012 Elsevier Ireland Ltd.
Please use this identifier to cite or link to this item: