An exponential family model for clustered multivariate binary data

Publication Type:
Journal Article
Environmetrics, 1999, 10 (3), pp. 279 - 300
Issue Date:
Filename Description Size
Thumbnail2011008580OK.pdf787.06 kB
Adobe PDF
Full metadata record
This paper focuses on the analysis of clustered multivariate binary data that arise from developmental toxicity studies. In these studies, pregnant mice are exposed to chemicals to assess possible adverse effects on developing fetuses. Multivariate binary outcomes arise when each fetus in a litter is assessed for the presence of malformations and/or low birth weight. We analyse the data using a multivariate exponential family model which is flexible in terms of allowing response rates to depend on cluster size. Maximum likelihood estimation of model parameters and the construction of score tests for dose effect are discussed.
Please use this identifier to cite or link to this item: