On the representativeness assumption in prevalence tests of carcinogenicity

Blackwell Publ Ltd
Publication Type:
Journal Article
Journal of the Royal Statistical Society Series C: Applied Statistics, 1985, 34 (1), pp. 54 - 62
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Conditions for the validityo f the Hoel-Walburga nd Peto tests, which compare dose groups with respect to tumour prevalence,a re replaced by a more generalc ondition, representativenesAs. large carcinogenicityex perimentp rovideda unique opportunityt o assess empiricallyif t his conditionh olds. Though representativenesws as generallyv iolated, neithert he Hoel-Walburgn or the Peto tests were seriouslyd istorted.A nalyticc onsiderationss uggestt hat such robustnessc an occur in manys ituations
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