Metalloproteomics: principles, challenges and applications to neurodegeneration

Publisher:
Frontiers
Publication Type:
Journal article
Citation:
Lothian, Amber et al. 2013, 'Metalloproteomics: principles, challenges and applications to neurodegeneration', Frontiers in Aging Neuroscience, vol. 5, no. 1, pp. 35-1-35-7.
Issue Date:
2013
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2012008358OK.pdf832.96 kB
Adobe PDF
Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process. Thus, the future of metals in neurobiology will rely more on detailed information regarding what metalloenzymes are present and how they are involved in the pathophysiology of disease. To gain this detailed information, we will rely less on bulk measures of the amount of a trace elements in a particular tissue and turn to metalloproteomic techniques to help elucidate both metalloprotein structure and function. Recent advances in metalloproteomics will translate to a richer understanding of the mechanism and precise role of metalloenzymes and proteins in the brain.
Please use this identifier to cite or link to this item: