Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women's health

Vashum, KP; McEvoy, M; Shi, Z; Milton, AH; Islam, MR; Sibbritt, D; Patterson, A; Byles, J; Loxton, D; Attia, J

Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women's health

Vashum, KP McEvoy, M Shi, Z Milton, AH Islam, MR Sibbritt, D

Patterson, A Byles, J Loxton, D Attia, J

Permalink

Publication Type:: Journal Article
Citation:: BMC Endocrine Disorders, 2013, 13
Issue Date:: 2013-10-04

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download full textAdobe PDF (171.79 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Vashum, KP	en_US
dc.contributor.author	McEvoy, M	en_US
dc.contributor.author	Shi, Z	en_US
dc.contributor.author	Milton, AH	en_US
dc.contributor.author	Islam, MR	en_US
dc.contributor.author	Sibbritt, D https://orcid.org/0000-0003-3561-9447	en_US
dc.contributor.author	Patterson, A	en_US
dc.contributor.author	Byles, J	en_US
dc.contributor.author	Loxton, D	en_US
dc.contributor.author	Attia, J	en_US
dc.date.available	2013-09-18	en_US
dc.date.issued	2013-10-04	en_US
dc.identifier.citation	BMC Endocrine Disorders, 2013, 13	en_US
dc.identifier.uri	http://hdl.handle.net/10453/29894
dc.description.abstract	Background: Animal studies have shown that zinc intake has protective effects against type 2 diabetes, but few studies have been conducted to examine this relationship in humans. The aim of this study is to investigate if dietary zinc is associated with risk of type 2 diabetes in a longitudinal study of mid-age Australian women. Methods: Data were collected from a cohort of women aged 45-50 years at baseline, participating in the Australian Longitudinal Study on Women's Health. A validated food frequency questionnaire was used to assess dietary intake and other nutrients. Predictors of 6-year incidence of type 2 diabetes were examined using multivariable logistic regression. Results: From 8921 participants, 333 incident cases of type 2 diabetes were identified over 6 years of follow-up. After adjustment for dietary and non-dietary factors, the highest quintile dietary zinc intake had almost half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I. 0.32-0.77) compared with the lowest quintile. Similar findings were observed for the zinc/iron ratio; the highest quintile had half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I 0.30-0.83) after multivariable adjustment of covariates. Conclusions: Higher total dietary zinc intake and high zinc/iron ratio are associated with lower risk of type 2 diabetes in women. This finding is a positive step towards further research to determine if zinc supplementation may reduce the risk of developing type 2 diabetes. © 2013 Vashum et al.; licensee BioMed Central Ltd.	en_US
dc.relation.ispartof	BMC Endocrine Disorders	en_US
dc.relation.isbasedon	10.1186/1472-6823-13-40	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.title	Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women's health	en_US
dc.type	Journal Article
utslib.citation.volume	13	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	13	en_US

Abstract:

Background: Animal studies have shown that zinc intake has protective effects against type 2 diabetes, but few studies have been conducted to examine this relationship in humans. The aim of this study is to investigate if dietary zinc is associated with risk of type 2 diabetes in a longitudinal study of mid-age Australian women. Methods: Data were collected from a cohort of women aged 45-50 years at baseline, participating in the Australian Longitudinal Study on Women's Health. A validated food frequency questionnaire was used to assess dietary intake and other nutrients. Predictors of 6-year incidence of type 2 diabetes were examined using multivariable logistic regression. Results: From 8921 participants, 333 incident cases of type 2 diabetes were identified over 6 years of follow-up. After adjustment for dietary and non-dietary factors, the highest quintile dietary zinc intake had almost half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I. 0.32-0.77) compared with the lowest quintile. Similar findings were observed for the zinc/iron ratio; the highest quintile had half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I 0.30-0.83) after multivariable adjustment of covariates. Conclusions: Higher total dietary zinc intake and high zinc/iron ratio are associated with lower risk of type 2 diabetes in women. This finding is a positive step towards further research to determine if zinc supplementation may reduce the risk of developing type 2 diabetes. © 2013 Vashum et al.; licensee BioMed Central Ltd.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/29894