Synthesis and sensing properties of a new carbazole fluorosensor for detection of abacavir

Cywinski, PJ; Idzik, KR; Cranfield, CG; Beckert, R; Mohr, GJ

Synthesis and sensing properties of a new carbazole fluorosensor for detection of abacavir

Cywinski, PJ Idzik, KR Cranfield, CG

Beckert, R Mohr, GJ

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Publication Type:: Journal Article
Citation:: Supramolecular Chemistry, 2010, 22 (10), pp. 598 - 602
Issue Date:: 2010-10-01

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Field	Value	Language
dc.contributor.author	Cywinski, PJ	en_US
dc.contributor.author	Idzik, KR	en_US
dc.contributor.author	Cranfield, CG https://orcid.org/0000-0003-3608-5440	en_US
dc.contributor.author	Beckert, R	en_US
dc.contributor.author	Mohr, GJ	en_US
dc.date.issued	2010-10-01	en_US
dc.identifier.citation	Supramolecular Chemistry, 2010, 22 (10), pp. 598 - 602	en_US
dc.identifier.issn	1061-0278	en_US
dc.identifier.uri	http://hdl.handle.net/10453/30151
dc.description.abstract	An abacavir-targeted fluorosensor based on the carbazole moiety has been synthesised and characterised. Recognition of abacavir is by base pairing between a uracil moiety present in the fluorosensor and the guanine moiety of abacavir. The fluorosensor exhibits five-fold quenching in the presence of 50M abacavir. Its sensitivity to abacavir is superior to that of other reverse transcriptase inhibitors: zidovudine, lamivudine and didanosine. Due to its high sensitivity, this fluorosensor has the potential to be used in multi-analyte array-based detection platforms as well as in microfluidics systems. © 2010 Taylor & Francis.	en_US
dc.relation.ispartof	Supramolecular Chemistry	en_US
dc.relation.isbasedon	10.1080/10610278.2010.506541	en_US
dc.subject.classification	Organic Chemistry	en_US
dc.title	Synthesis and sensing properties of a new carbazole fluorosensor for detection of abacavir	en_US
dc.type	Journal Article
utslib.citation.volume	10	en_US
utslib.citation.volume	22	en_US
utslib.for	03 Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	10	en_US
pubs.publication-status	Published	en_US
pubs.volume	22	en_US

Abstract:

An abacavir-targeted fluorosensor based on the carbazole moiety has been synthesised and characterised. Recognition of abacavir is by base pairing between a uracil moiety present in the fluorosensor and the guanine moiety of abacavir. The fluorosensor exhibits five-fold quenching in the presence of 50M abacavir. Its sensitivity to abacavir is superior to that of other reverse transcriptase inhibitors: zidovudine, lamivudine and didanosine. Due to its high sensitivity, this fluorosensor has the potential to be used in multi-analyte array-based detection platforms as well as in microfluidics systems. © 2010 Taylor & Francis.

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