New sequence variants associated with bone mineral density

Styrkarsdottir, U; Halldorsson, BV; Gretarsdottir, S; Gudbjartsson, DF; Walters, GB; Ingvarsson, T; Jonsdottir, T; Saemundsdottir, J; Snorradóttir, S; Center, JR; Nguyen, TV; Alexandersen, P; Gulcher, JR; Eisman, JA; Christiansen, C; Sigurdsson, G; Kong, A; Thorsteinsdottir, U; Stefansson, K

New sequence variants associated with bone mineral density

Styrkarsdottir, U Halldorsson, BV Gretarsdottir, S Gudbjartsson, DF Walters, GB Ingvarsson, T Jonsdottir, T Saemundsdottir, J Snorradóttir, S Center, JR Nguyen, TV

Alexandersen, P Gulcher, JR Eisman, JA Christiansen, C Sigurdsson, G Kong, A Thorsteinsdottir, U Stefansson, K

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Publication Type:: Journal Article
Citation:: Nature Genetics, 2009, 41 (1), pp. 15 - 17
Issue Date:: 2009-01-01

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Field	Value	Language
dc.contributor.author	Styrkarsdottir, U	en_US
dc.contributor.author	Halldorsson, BV	en_US
dc.contributor.author	Gretarsdottir, S	en_US
dc.contributor.author	Gudbjartsson, DF	en_US
dc.contributor.author	Walters, GB	en_US
dc.contributor.author	Ingvarsson, T	en_US
dc.contributor.author	Jonsdottir, T	en_US
dc.contributor.author	Saemundsdottir, J	en_US
dc.contributor.author	Snorradóttir, S	en_US
dc.contributor.author	Center, JR	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.contributor.author	Alexandersen, P	en_US
dc.contributor.author	Gulcher, JR	en_US
dc.contributor.author	Eisman, JA	en_US
dc.contributor.author	Christiansen, C	en_US
dc.contributor.author	Sigurdsson, G	en_US
dc.contributor.author	Kong, A	en_US
dc.contributor.author	Thorsteinsdottir, U	en_US
dc.contributor.author	Stefansson, K	en_US
dc.date.available	2008-10-14	en_US
dc.date.issued	2009-01-01	en_US
dc.identifier.citation	Nature Genetics, 2009, 41 (1), pp. 15 - 17	en_US
dc.identifier.issn	1061-4036	en_US
dc.identifier.uri	http://hdl.handle.net/10453/32574
dc.description.abstract	In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density. © 2009 Nature America, Inc. All rights reserved.	en_US
dc.relation.ispartof	Nature Genetics	en_US
dc.relation.isbasedon	10.1038/ng.284	en_US
dc.subject.classification	Developmental Biology	en_US
dc.subject.mesh	Chromosomes, Human, Pair 17	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Wounds and Injuries	en_US
dc.subject.mesh	Base Sequence	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Polymorphism, Single Nucleotide	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Fractures, Bone	en_US
dc.subject.mesh	Genome-Wide Association Study	en_US
dc.title	New sequence variants associated with bone mineral density	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	41	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	41	en_US

Abstract:

In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density. © 2009 Nature America, Inc. All rights reserved.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/32574