Decreased serum zinc is an effect of ageing and not Alzheimer's disease

Rembach, A; Hare, DJ; Doecke, JD; Burnham, SC; Volitakis, I; Fowler, CJ; Cherny, RA; McLean, C; Grimm, R; Martins, R; Ames, D; Masters, CL; Bush, AI; Roberts, BR

Decreased serum zinc is an effect of ageing and not Alzheimer's disease

Rembach, A Hare, DJ

Doecke, JD Burnham, SC Volitakis, I Fowler, CJ Cherny, RA McLean, C Grimm, R Martins, R Ames, D Masters, CL Bush, AI Roberts, BR

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Publication Type:: Journal Article
Citation:: Metallomics, 2014, 6 (7), pp. 1216 - 1219
Issue Date:: 2014-01-01

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Field	Value	Language
dc.contributor.author	Rembach, A	en_US
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Doecke, JD	en_US
dc.contributor.author	Burnham, SC	en_US
dc.contributor.author	Volitakis, I	en_US
dc.contributor.author	Fowler, CJ	en_US
dc.contributor.author	Cherny, RA	en_US
dc.contributor.author	McLean, C	en_US
dc.contributor.author	Grimm, R	en_US
dc.contributor.author	Martins, R	en_US
dc.contributor.author	Ames, D	en_US
dc.contributor.author	Masters, CL	en_US
dc.contributor.author	Bush, AI	en_US
dc.contributor.author	Roberts, BR	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Metallomics, 2014, 6 (7), pp. 1216 - 1219	en_US
dc.identifier.issn	1756-5901	en_US
dc.identifier.uri	http://hdl.handle.net/10453/32810
dc.description.abstract	We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed. © 2014 the Partner Organisations.	en_US
dc.relation.ispartof	Metallomics	en_US
dc.relation.isbasedon	10.1039/c4mt00060a	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Alzheimer Disease	en_US
dc.subject.mesh	Zinc	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Aging	en_US
dc.subject.mesh	Apolipoprotein E4	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Biomarkers	en_US
dc.subject.mesh	Cognitive Dysfunction	en_US
dc.subject.mesh	Cohort Studies	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Life Style	en_US
dc.subject.mesh	Longitudinal Studies	en_US
dc.subject.mesh	Male	en_US
dc.title	Decreased serum zinc is an effect of ageing and not Alzheimer's disease	en_US
dc.type	Journal Article
utslib.citation.volume	7	en_US
utslib.citation.volume	6	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	03 Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	7	en_US
pubs.publication-status	Published	en_US
pubs.volume	6	en_US

Abstract:

We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed. © 2014 the Partner Organisations.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/32810