Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo

Ho, KKK; Cole, N; Chen, R; Willcox, MDP; Rice, SA; Kumar, N

Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo

Ho, KKK Cole, N

Chen, R Willcox, MDP Rice, SA

Kumar, N

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Publication Type:: Journal Article
Citation:: Antimicrobial Agents and Chemotherapy, 2012, 56 (2), pp. 1138 - 1141
Issue Date:: 2012-02-01

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Field	Value	Language
dc.contributor.author	Ho, KKK	en_US
dc.contributor.author	Cole, N https://orcid.org/0000-0002-9866-4694	en_US
dc.contributor.author	Chen, R	en_US
dc.contributor.author	Willcox, MDP	en_US
dc.contributor.author	Rice, SA https://orcid.org/0000-0002-9486-2343	en_US
dc.contributor.author	Kumar, N	en_US
dc.date.issued	2012-02-01	en_US
dc.identifier.citation	Antimicrobial Agents and Chemotherapy, 2012, 56 (2), pp. 1138 - 1141	en_US
dc.identifier.issn	0066-4804	en_US
dc.identifier.uri	http://hdl.handle.net/10453/37807
dc.description.abstract	Antibiotic-resistant Staphylococcus aureus is of great concern, as it causes a wide range of life-threatening infections. The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates of S. aureus in vitro in a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal infection in a subcutaneous infection model. Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications. Copyright © 2012, American Society for Microbiology. All Rights Reserved.	en_US
dc.relation.ispartof	Antimicrobial Agents and Chemotherapy	en_US
dc.relation.isbasedon	10.1128/AAC.05814-11	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Staphylococcus aureus	en_US
dc.subject.mesh	Staphylococcal Skin Infections	en_US
dc.subject.mesh	Prosthesis-Related Infections	en_US
dc.subject.mesh	Pyrroles	en_US
dc.subject.mesh	Polymers	en_US
dc.subject.mesh	Acrylic Resins	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Microspheres	en_US
dc.subject.mesh	Male	en_US
dc.title	Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	56	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1108 Medical Microbiology	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	56	en_US

Abstract:

Antibiotic-resistant Staphylococcus aureus is of great concern, as it causes a wide range of life-threatening infections. The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates of S. aureus in vitro in a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal infection in a subcutaneous infection model. Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications. Copyright © 2012, American Society for Microbiology. All Rights Reserved.

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http://hdl.handle.net/10453/37807