Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake

Cardoso, BR; Busse, AL; Hare, DJ; Cominetti, C; Horst, MA; McColl, G; Magaldi, RM; Jacob-Filho, W; Cozzolino, SMF

Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake

Cardoso, BR Busse, AL Hare, DJ

Cominetti, C Horst, MA McColl, G Magaldi, RM Jacob-Filho, W Cozzolino, SMF

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Publication Type:: Journal Article
Citation:: Food and Function, 2016, 7 (2), pp. 825 - 833
Issue Date:: 2016-02-01

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Field	Value	Language
dc.contributor.author	Cardoso, BR	en_US
dc.contributor.author	Busse, AL	en_US
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Cominetti, C	en_US
dc.contributor.author	Horst, MA	en_US
dc.contributor.author	McColl, G	en_US
dc.contributor.author	Magaldi, RM	en_US
dc.contributor.author	Jacob-Filho, W	en_US
dc.contributor.author	Cozzolino, SMF	en_US
dc.date.issued	2016-02-01	en_US
dc.identifier.citation	Food and Function, 2016, 7 (2), pp. 825 - 833	en_US
dc.identifier.issn	2042-6496	en_US
dc.identifier.uri	http://hdl.handle.net/10453/41098
dc.description.abstract	© The Royal Society of Chemistry 2015. Selenoproteins play important roles in antioxidant mechanisms, and are thus hypothesised to have some involvement in the pathology of certain types of dementia. Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are both thought to involve impaired biological activity of certain selenoproteins. Previously, supplementation with a selenium-rich Brazil nut (Bertholletia excelsa) has shown potential in reducing cognitive decline in MCI patients, and could prove to be a safe and effective nutritional approach early in the disease process to slow decline. Here, we have conducted a pilot study that examined the effects of a range of single nucleotide polymorphisms (SNPs) in genes encoding the selenoproteins glutathione peroxidase (GPX1) and selenoprotein P (SEPP) in response to selenium supplementation via dietary Brazil nuts, including selenium status, oxidative stress parameters and GPX1 and SEPP gene expression. Our data suggest that GPX1 Pro198Leu rs1050450 genotypes may differentially affect the selenium status and GPx activity. Moreover, rs7579 and rs3877899 SNPs in SEPP gene, as well as GPX1 rs1050450 genotypes can influence the expression of GPX1 and SEPP mRNA in response to Brazil nuts intake. This small study gives cause for larger investigations into the role of these SNPs in both the selenium status and response to selenium dietary intake, especially in chronic degenerative conditions like MCI and AD.	en_US
dc.relation.ispartof	Food and Function	en_US
dc.relation.isbasedon	10.1039/c5fo01270h	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Bertholletia	en_US
dc.subject.mesh	Nuts	en_US
dc.subject.mesh	Selenium	en_US
dc.subject.mesh	Glutathione Peroxidase	en_US
dc.subject.mesh	Pilot Projects	en_US
dc.subject.mesh	Genotype	en_US
dc.subject.mesh	Polymorphism, Single Nucleotide	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Brazil	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Selenoprotein P	en_US
dc.subject.mesh	Cognitive Dysfunction	en_US
dc.title	Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	7	en_US
utslib.for	0908 Food Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	7	en_US

Abstract:

© The Royal Society of Chemistry 2015. Selenoproteins play important roles in antioxidant mechanisms, and are thus hypothesised to have some involvement in the pathology of certain types of dementia. Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are both thought to involve impaired biological activity of certain selenoproteins. Previously, supplementation with a selenium-rich Brazil nut (Bertholletia excelsa) has shown potential in reducing cognitive decline in MCI patients, and could prove to be a safe and effective nutritional approach early in the disease process to slow decline. Here, we have conducted a pilot study that examined the effects of a range of single nucleotide polymorphisms (SNPs) in genes encoding the selenoproteins glutathione peroxidase (GPX1) and selenoprotein P (SEPP) in response to selenium supplementation via dietary Brazil nuts, including selenium status, oxidative stress parameters and GPX1 and SEPP gene expression. Our data suggest that GPX1 Pro198Leu rs1050450 genotypes may differentially affect the selenium status and GPx activity. Moreover, rs7579 and rs3877899 SNPs in SEPP gene, as well as GPX1 rs1050450 genotypes can influence the expression of GPX1 and SEPP mRNA in response to Brazil nuts intake. This small study gives cause for larger investigations into the role of these SNPs in both the selenium status and response to selenium dietary intake, especially in chronic degenerative conditions like MCI and AD.

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http://hdl.handle.net/10453/41098