Fighting the global pest problem: Preface to the special Toxicon issue on insecticidal toxins and their potential for insect pest control

Nicholson, GM

Fighting the global pest problem: Preface to the special Toxicon issue on insecticidal toxins and their potential for insect pest control

Nicholson, GM

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Publication Type:: Journal Article
Citation:: Toxicon, 2007, 49 (4), pp. 413 - 422
Issue Date:: 2007-03-15

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Field	Value	Language
dc.contributor.author	Nicholson, GM https://orcid.org/0000-0002-4277-4296	en_US
dc.date.available	2006-11-17	en_US
dc.date.issued	2007-03-15	en_US
dc.identifier.citation	Toxicon, 2007, 49 (4), pp. 413 - 422	en_US
dc.identifier.issn	0041-0101	en_US
dc.identifier.uri	http://hdl.handle.net/10453/4467
dc.description.abstract	Arthropod pests are responsible for major crop devastation and are vectors for the transmission of new and re-emerging diseases in humans and livestock. Despite many years of effective control by conventional agrochemical insecticides, a number of factors are threatening the effectiveness and continued use of these agents. These include the development of insecticide resistance and use-cancellation or de-registration of some insecticides due to human health and environmental concerns. Several approaches are being investigated for the design of new (bio)pesticides. These include the development of transgenic plants and recombinant baculoviruses as delivery systems for a variety of insect-selective toxins. Additional approaches for the development of foliar sprays include the rational design of peptidomimetics based on the key residues of these toxins that interact with the insect target. This special issue provides an overview of these phyletically selective animal, plant and microbial toxins and their diverse mechanisms of action to paralyze or kill arthropods. In addition, it reviews their potential for biopesticide discovery and validation of novel insecticide targets and provides an overview of the strengths and weaknesses of biopesticides in the global control of arthropod pests. © 2007 Elsevier Ltd. All rights reserved.	en_US
dc.relation.ispartof	Toxicon	en_US
dc.relation.isbasedon	10.1016/j.toxicon.2006.11.028	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Organisms, Genetically Modified	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Insects	en_US
dc.subject.mesh	Baculoviridae	en_US
dc.subject.mesh	Plant Leaves	en_US
dc.subject.mesh	Insecticides	en_US
dc.subject.mesh	Disease Vectors	en_US
dc.subject.mesh	Pest Control, Biological	en_US
dc.subject.mesh	Insecticide Resistance	en_US
dc.subject.mesh	Biomimetic Materials	en_US
dc.subject.mesh	World Health	en_US
dc.subject.mesh	Toxins, Biological	en_US
dc.subject.mesh	Global Health	en_US
dc.subject.mesh	Insecta	en_US
dc.title	Fighting the global pest problem: Preface to the special Toxicon issue on insecticidal toxins and their potential for insect pest control	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	49	en_US
utslib.for	111506 Toxicology (incl. Clinical Toxicology)	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	49	en_US

Abstract:

Arthropod pests are responsible for major crop devastation and are vectors for the transmission of new and re-emerging diseases in humans and livestock. Despite many years of effective control by conventional agrochemical insecticides, a number of factors are threatening the effectiveness and continued use of these agents. These include the development of insecticide resistance and use-cancellation or de-registration of some insecticides due to human health and environmental concerns. Several approaches are being investigated for the design of new (bio)pesticides. These include the development of transgenic plants and recombinant baculoviruses as delivery systems for a variety of insect-selective toxins. Additional approaches for the development of foliar sprays include the rational design of peptidomimetics based on the key residues of these toxins that interact with the insect target. This special issue provides an overview of these phyletically selective animal, plant and microbial toxins and their diverse mechanisms of action to paralyze or kill arthropods. In addition, it reviews their potential for biopesticide discovery and validation of novel insecticide targets and provides an overview of the strengths and weaknesses of biopesticides in the global control of arthropod pests. © 2007 Elsevier Ltd. All rights reserved.

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http://hdl.handle.net/10453/4467