The number, organization, and size of polymorphic membrane protein coding sequences as well as the most conserved Pmp protein differ within and across chlamydia species

Van Lent, S; Creasy, HH; Myers, GSA; Vanrompay, D

The number, organization, and size of polymorphic membrane protein coding sequences as well as the most conserved Pmp protein differ within and across chlamydia species

Van Lent, S Creasy, HH Myers, GSA

Vanrompay, D

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Publication Type:: Journal Article
Citation:: Journal of Molecular Microbiology and Biotechnology, 2016, 26 (5), pp. 333 - 344
Issue Date:: 2016-08-01

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Field	Value	Language
dc.contributor.author	Van Lent, S	en_US
dc.contributor.author	Creasy, HH	en_US
dc.contributor.author	Myers, GSA https://orcid.org/0000-0002-4756-4810	en_US
dc.contributor.author	Vanrompay, D	en_US
dc.date.available	2016-05-25	en_US
dc.date.issued	2016-08-01	en_US
dc.identifier.citation	Journal of Molecular Microbiology and Biotechnology, 2016, 26 (5), pp. 333 - 344	en_US
dc.identifier.issn	1464-1801	en_US
dc.identifier.uri	http://hdl.handle.net/10453/98652
dc.description.abstract	© 2016 S. Karger AG, Basel. Variation is a central trait of the polymorphic membrane protein (Pmp) family. The number of pmp coding sequences differs between Chlamydia species, but it is unknown whether the number of pmp coding sequences is constant within a Chlamydia species. The level of conservation of the Pmp proteins has previously only been determined for Chlamydia trachomatis. As different Pmp proteins might be indispensible for the pathogenesis of different Chlamydia species, this study investigated the conservation of Pmp proteins both within and across C. trachomatis,C. pneumoniae,C. abortus, and C. psittaci. The pmp coding sequences were annotated in 16 C. trachomatis, 6 C. pneumoniae, 2 C. abortus, and 16 C. psittaci genomes. The number and organization of polymorphic membrane coding sequences differed within and across the analyzed Chlamydia species. The length of coding sequences of pmpA,pmpB, and pmpH was conserved among all analyzed genomes, while the length of pmpE/F and pmpG, and remarkably also of the subtype pmpD, differed among the analyzed genomes. PmpD, PmpA, PmpH, and PmpA were the most conserved Pmp in C. trachomatis,C. pneumoniae,C. abortus, and C. psittaci, respectively. PmpB was the most conserved Pmp across the 4 analyzed Chlamydia species.	en_US
dc.relation.ispartof	Journal of Molecular Microbiology and Biotechnology	en_US
dc.relation.isbasedon	10.1159/000447092	en_US
dc.subject.classification	Biotechnology	en_US
dc.subject.mesh	Chlamydia	en_US
dc.subject.mesh	Bacterial Outer Membrane Proteins	en_US
dc.subject.mesh	Phylogeny	en_US
dc.subject.mesh	Conserved Sequence	en_US
dc.subject.mesh	Synteny	en_US
dc.subject.mesh	Gene Order	en_US
dc.subject.mesh	Genetic Variation	en_US
dc.title	The number, organization, and size of polymorphic membrane protein coding sequences as well as the most conserved Pmp protein differ within and across chlamydia species	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	26	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	10 Technology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	26	en_US

Abstract:

© 2016 S. Karger AG, Basel. Variation is a central trait of the polymorphic membrane protein (Pmp) family. The number of pmp coding sequences differs between Chlamydia species, but it is unknown whether the number of pmp coding sequences is constant within a Chlamydia species. The level of conservation of the Pmp proteins has previously only been determined for Chlamydia trachomatis. As different Pmp proteins might be indispensible for the pathogenesis of different Chlamydia species, this study investigated the conservation of Pmp proteins both within and across C. trachomatis,C. pneumoniae,C. abortus, and C. psittaci. The pmp coding sequences were annotated in 16 C. trachomatis, 6 C. pneumoniae, 2 C. abortus, and 16 C. psittaci genomes. The number and organization of polymorphic membrane coding sequences differed within and across the analyzed Chlamydia species. The length of coding sequences of pmpA,pmpB, and pmpH was conserved among all analyzed genomes, while the length of pmpE/F and pmpG, and remarkably also of the subtype pmpD, differed among the analyzed genomes. PmpD, PmpA, PmpH, and PmpA were the most conserved Pmp in C. trachomatis,C. pneumoniae,C. abortus, and C. psittaci, respectively. PmpB was the most conserved Pmp across the 4 analyzed Chlamydia species.

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http://hdl.handle.net/10453/98652