Oxidative stress in prostate cancer patients: A systematic review of case control studies

Oh, B; Figtree, G; Costa, D; Eade, T; Hruby, G; Lim, S; Elfiky, A; Martine, N; Rosenthal, D; Clarke, S; Back, M

Oxidative stress in prostate cancer patients: A systematic review of case control studies

Oh, B

Figtree, G Costa, D Eade, T Hruby, G Lim, S Elfiky, A Martine, N Rosenthal, D Clarke, S Back, M

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Publication Type:: Journal Article
Citation:: Prostate International, 2016, 4 (3), pp. 71 - 87
Issue Date:: 2016-09-01

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Field	Value	Language
dc.contributor.author	Oh, B https://orcid.org/0000-0001-6063-4548	en_US
dc.contributor.author	Figtree, G	en_US
dc.contributor.author	Costa, D	en_US
dc.contributor.author	Eade, T	en_US
dc.contributor.author	Hruby, G	en_US
dc.contributor.author	Lim, S	en_US
dc.contributor.author	Elfiky, A	en_US
dc.contributor.author	Martine, N	en_US
dc.contributor.author	Rosenthal, D	en_US
dc.contributor.author	Clarke, S	en_US
dc.contributor.author	Back, M	en_US
dc.date.available	2016-05-16	en_US
dc.date.issued	2016-09-01	en_US
dc.identifier.citation	Prostate International, 2016, 4 (3), pp. 71 - 87	en_US
dc.identifier.issn	2287-8882	en_US
dc.identifier.uri	http://hdl.handle.net/10453/99271
dc.description.abstract	© 2016 Background Prostate cancer (PCa) is the most common cancer in men in Western countries. In-vitro and in-vivo studies suggest that oxidative stress (OS) and antioxidants play a key role in the pathogenesis of chronic diseases including PCa, which is promoted by the production of reactive oxygen species and impaired antioxidant defense mechanisms. This study evaluates the association between OS and men with PCa. Methods A literature search was carried out on Medline, PubMed, and ScienceDirect databases, as well as manual searches from inception up to August 2015 using the keywords “Oxidative stress” or “Reactive oxygen species” or “Lipid peroxidation” AND “Prostate cancer.” All studies including data on the measurement of OS biomarkers in PCa were included. Results Twenty-three case control studies were retrieved with sample sizes ranging from 15 to 3,613 (6,439 participants in total). Markers of OS were significantly higher in patients with PCa compared with control groups in 21 studies. Two self-controlled case studies comparing OS between PCa cells and non-PCa cells in tissue biopsies found OS to be statistically higher in PCa cancer cells. Results on markers of antioxidant capacity (superoxide dismutase, catalase, glutathione, glutathione reductase, glutathione peroxidase, uric acid, lutein, lycopene, beta carotein, vitamin A, vitamin C, vitamin E, and total antioxidants) were not completely consistent in their association with PCa. Conclusions Upregulated OS profiles and impairment of antioxidant defense systems may play a role in men with PCa. To confirm these findings, robust clinical trials utilizing a personalized approach which monitors both OS and antioxidant markers during therapy are warranted.	en_US
dc.relation.ispartof	Prostate International	en_US
dc.relation.isbasedon	10.1016/j.prnil.2016.05.002	en_US
dc.title	Oxidative stress in prostate cancer patients: A systematic review of case control studies	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	4	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Medical and Molecular Sciences
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	4	en_US

Abstract:

© 2016 Background Prostate cancer (PCa) is the most common cancer in men in Western countries. In-vitro and in-vivo studies suggest that oxidative stress (OS) and antioxidants play a key role in the pathogenesis of chronic diseases including PCa, which is promoted by the production of reactive oxygen species and impaired antioxidant defense mechanisms. This study evaluates the association between OS and men with PCa. Methods A literature search was carried out on Medline, PubMed, and ScienceDirect databases, as well as manual searches from inception up to August 2015 using the keywords “Oxidative stress” or “Reactive oxygen species” or “Lipid peroxidation” AND “Prostate cancer.” All studies including data on the measurement of OS biomarkers in PCa were included. Results Twenty-three case control studies were retrieved with sample sizes ranging from 15 to 3,613 (6,439 participants in total). Markers of OS were significantly higher in patients with PCa compared with control groups in 21 studies. Two self-controlled case studies comparing OS between PCa cells and non-PCa cells in tissue biopsies found OS to be statistically higher in PCa cancer cells. Results on markers of antioxidant capacity (superoxide dismutase, catalase, glutathione, glutathione reductase, glutathione peroxidase, uric acid, lutein, lycopene, beta carotein, vitamin A, vitamin C, vitamin E, and total antioxidants) were not completely consistent in their association with PCa. Conclusions Upregulated OS profiles and impairment of antioxidant defense systems may play a role in men with PCa. To confirm these findings, robust clinical trials utilizing a personalized approach which monitors both OS and antioxidant markers during therapy are warranted.

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http://hdl.handle.net/10453/99271