Propriospinal cutaneous-induced EMG suppression is unaltered by anodal tDCS of healthy motor cortex

McCambridge, AB; Stinear, JW; Peek, S; Byblow, WD

Propriospinal cutaneous-induced EMG suppression is unaltered by anodal tDCS of healthy motor cortex

McCambridge, AB

Stinear, JW Peek, S Byblow, WD

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Publication Type:: Journal Article
Citation:: Clinical Neurophysiology, 2017, 128 (9), pp. 1608 - 1616
Issue Date:: 2017-09-01

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Field	Value	Language
dc.contributor.author	McCambridge, AB https://orcid.org/0000-0001-6822-4199	en_US
dc.contributor.author	Stinear, JW	en_US
dc.contributor.author	Peek, S	en_US
dc.contributor.author	Byblow, WD	en_US
dc.date.available	2017-06-10	en_US
dc.date.issued	2017-09-01	en_US
dc.identifier.citation	Clinical Neurophysiology, 2017, 128 (9), pp. 1608 - 1616	en_US
dc.identifier.issn	1388-2457	en_US
dc.identifier.uri	http://hdl.handle.net/10453/112140
dc.description.abstract	© 2017 International Federation of Clinical Neurophysiology Objective Cervical propriospinal premotoneurons (PN) relay descending motor commands and integrate peripheral afferent feedback. Effects of anodal transcranial direct current stimulation (a-tDCS) on propriospinal excitability in the upper limbs are unknown. Methods Healthy right-handed adults received a-tDCS or sham tDCS over primary motor cortex (M1) at 1 mA (Experiment 1, n = 18) or 2 mA current intensity (Experiment 2, n = 15). Propriospinal excitability was assessed by suppression of background electromyography (EMG) in extensor carpi radialis (ECR) from electrical stimulation of the superficial radial nerve during bilateral (Experiment 1 and 2) or unilateral (Experiment 2 only) activation of the left and/or right ECR. EMG suppression could be attributed to an early propriospinal component and late cortical component. Motor evoked potentials (MEP) were obtained as a manipulation check. Results Before tDCS, propriospinal-mediated cutaneous-induced suppression was present in each arm for early and late components. ECR MEP amplitude increased after 1 mA, but not 2 mA, a-tDCS. Neither 1 mA nor 2 mA a-tDCS modulated either component of ipsilateral or contralateral propriospinal excitability during bilateral or unilateral tasks. Conclusions Propriospinal-mediated cutaneous-induced suppression was not modulated by a-tDCS in healthy adults. Significance Reporting non-significant findings is paramount for the development of clinically-relevant tDCS protocols.	en_US
dc.relation.ispartof	Clinical Neurophysiology	en_US
dc.relation.isbasedon	10.1016/j.clinph.2017.06.035	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Motor Cortex	en_US
dc.subject.mesh	Spinal Cord	en_US
dc.subject.mesh	Motor Neurons	en_US
dc.subject.mesh	Spinal Nerves	en_US
dc.subject.mesh	Radial Nerve	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Electromyography	en_US
dc.subject.mesh	Double-Blind Method	en_US
dc.subject.mesh	Evoked Potentials, Motor	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Young Adult	en_US
dc.subject.mesh	Transcranial Direct Current Stimulation	en_US
dc.title	Propriospinal cutaneous-induced EMG suppression is unaltered by anodal tDCS of healthy motor cortex	en_US
dc.type	Journal Article
utslib.citation.volume	9	en_US
utslib.citation.volume	128	en_US
utslib.for	110317 Physiotherapy	en_US
utslib.for	09 Engineering	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.issue	9	en_US
pubs.publication-status	Published	en_US
pubs.volume	128	en_US

Abstract:

© 2017 International Federation of Clinical Neurophysiology Objective Cervical propriospinal premotoneurons (PN) relay descending motor commands and integrate peripheral afferent feedback. Effects of anodal transcranial direct current stimulation (a-tDCS) on propriospinal excitability in the upper limbs are unknown. Methods Healthy right-handed adults received a-tDCS or sham tDCS over primary motor cortex (M1) at 1 mA (Experiment 1, n = 18) or 2 mA current intensity (Experiment 2, n = 15). Propriospinal excitability was assessed by suppression of background electromyography (EMG) in extensor carpi radialis (ECR) from electrical stimulation of the superficial radial nerve during bilateral (Experiment 1 and 2) or unilateral (Experiment 2 only) activation of the left and/or right ECR. EMG suppression could be attributed to an early propriospinal component and late cortical component. Motor evoked potentials (MEP) were obtained as a manipulation check. Results Before tDCS, propriospinal-mediated cutaneous-induced suppression was present in each arm for early and late components. ECR MEP amplitude increased after 1 mA, but not 2 mA, a-tDCS. Neither 1 mA nor 2 mA a-tDCS modulated either component of ipsilateral or contralateral propriospinal excitability during bilateral or unilateral tasks. Conclusions Propriospinal-mediated cutaneous-induced suppression was not modulated by a-tDCS in healthy adults. Significance Reporting non-significant findings is paramount for the development of clinically-relevant tDCS protocols.

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http://hdl.handle.net/10453/112140