Vegetarianism, bone loss, fracture and vitamin D: A longitudinal study in Asian vegans and non-vegans

Ho-Pham, LT; Vu, BQ; Lai, TQ; Nguyen, ND; Nguyen, TV

Vegetarianism, bone loss, fracture and vitamin D: A longitudinal study in Asian vegans and non-vegans

Ho-Pham, LT Vu, BQ Lai, TQ Nguyen, ND Nguyen, TV

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Publication Type:: Journal Article
Citation:: European Journal of Clinical Nutrition, 2012, 66 (1), pp. 75 - 82
Issue Date:: 2012-01-01

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Field	Value	Language
dc.contributor.author	Ho-Pham, LT	en_US
dc.contributor.author	Vu, BQ	en_US
dc.contributor.author	Lai, TQ	en_US
dc.contributor.author	Nguyen, ND	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.date.issued	2012-01-01	en_US
dc.identifier.citation	European Journal of Clinical Nutrition, 2012, 66 (1), pp. 75 - 82	en_US
dc.identifier.issn	0954-3007	en_US
dc.identifier.uri	http://hdl.handle.net/10453/114797
dc.description.abstract	Background/Objectives:The effect of vegan diet on bone loss has not been studied. The aim of this study was to examine the association between veganism and bone loss in postmenopausal women.Subjects/Methods:The study was designed as a prospective longitudinal investigation with 210 women, including 105 vegans and 105 omnivores. Femoral neck (FN) bone mineral density (BMD) was measured in 2008 and 2010 by dual-energy X-ray absorptiometry (Hologic QDR4500). The incidence of vertebral fracture was ascertained by X-ray report. Serum levels of C-terminal telopeptide of type I collagen (ΒCTX) and N-terminal propeptide of type I procollagen (PINP) were measured by Roche Elecsys assays. Serum concentration of 25-hydroxyvitamin D and parathyroid hormone were measured by electrochemiluminescence.Results:Among the 210 women who initially participated in the study in 2008, 181 women had completed the study and 29 women were lost to follow-up. The rate of loss in FN BMD was -1.91±3.45%/year in omnivores and -0.86±3.81%/year (P=0.08) in vegans. Lower body weight, higher intakes of animal protein and lipid, and corticosteroid use were associated with greater rate of bone loss. The 2-year incidence of fracture was 5.7% (n5/88) in vegans, which was not significantly different from omnivores (5.4%, n6/93). There were no significant differences in ΒCTX and PINP between vegans and omnivores. The prevalence of vitamin D insufficiency in vegans was higher than in omnivores (73% versus 46%; P=0.0003).Conclusions:Vegan diet did not have adverse effect on bone loss and fracture. Corticosteroid use and high intakes of animal protein and animal lipid were negatively associated with bone loss. © 2012 Macmillan Publishers Limited All rights reserved.	en_US
dc.relation.ispartof	European Journal of Clinical Nutrition	en_US
dc.relation.isbasedon	10.1038/ejcn.2011.131	en_US
dc.subject.classification	Nutrition & Dietetics	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Osteoporosis, Postmenopausal	en_US
dc.subject.mesh	Bone Resorption	en_US
dc.subject.mesh	Vitamin D Deficiency	en_US
dc.subject.mesh	Body Weight	en_US
dc.subject.mesh	Collagen Type I	en_US
dc.subject.mesh	Adrenal Cortex Hormones	en_US
dc.subject.mesh	Dietary Fats	en_US
dc.subject.mesh	Vitamin D	en_US
dc.subject.mesh	Peptides	en_US
dc.subject.mesh	Dietary Proteins	en_US
dc.subject.mesh	Absorptiometry, Photon	en_US
dc.subject.mesh	Prevalence	en_US
dc.subject.mesh	Longitudinal Studies	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Diet, Vegetarian	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Asian Continental Ancestry Group	en_US
dc.subject.mesh	Vietnam	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Fractures, Bone	en_US
dc.subject.mesh	Lost to Follow-Up	en_US
dc.subject.mesh	Feeding Behavior	en_US
dc.title	Vegetarianism, bone loss, fracture and vitamin D: A longitudinal study in Asian vegans and non-vegans	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	66	en_US
utslib.for	1111 Nutrition and Dietetics	en_US
utslib.for	0908 Food Sciences	en_US
utslib.for	1106 Human Movement and Sports Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	66	en_US

Abstract:

Background/Objectives:The effect of vegan diet on bone loss has not been studied. The aim of this study was to examine the association between veganism and bone loss in postmenopausal women.Subjects/Methods:The study was designed as a prospective longitudinal investigation with 210 women, including 105 vegans and 105 omnivores. Femoral neck (FN) bone mineral density (BMD) was measured in 2008 and 2010 by dual-energy X-ray absorptiometry (Hologic QDR4500). The incidence of vertebral fracture was ascertained by X-ray report. Serum levels of C-terminal telopeptide of type I collagen (ΒCTX) and N-terminal propeptide of type I procollagen (PINP) were measured by Roche Elecsys assays. Serum concentration of 25-hydroxyvitamin D and parathyroid hormone were measured by electrochemiluminescence.Results:Among the 210 women who initially participated in the study in 2008, 181 women had completed the study and 29 women were lost to follow-up. The rate of loss in FN BMD was -1.91±3.45%/year in omnivores and -0.86±3.81%/year (P=0.08) in vegans. Lower body weight, higher intakes of animal protein and lipid, and corticosteroid use were associated with greater rate of bone loss. The 2-year incidence of fracture was 5.7% (n5/88) in vegans, which was not significantly different from omnivores (5.4%, n6/93). There were no significant differences in ΒCTX and PINP between vegans and omnivores. The prevalence of vitamin D insufficiency in vegans was higher than in omnivores (73% versus 46%; P=0.0003).Conclusions:Vegan diet did not have adverse effect on bone loss and fracture. Corticosteroid use and high intakes of animal protein and animal lipid were negatively associated with bone loss. © 2012 Macmillan Publishers Limited All rights reserved.

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http://hdl.handle.net/10453/114797