Association between lean mass, fat mass, and bone mineral density: A meta-analysis

Ho-Pham, LT; Nguyen, UDT; Nguyen, TV

Association between lean mass, fat mass, and bone mineral density: A meta-analysis

Ho-Pham, LT Nguyen, UDT Nguyen, TV

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Publication Type:: Journal Article
Citation:: Journal of Clinical Endocrinology and Metabolism, 2014, 99 (1), pp. 30 - 38
Issue Date:: 2014-01-01

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Field	Value	Language
dc.contributor.author	Ho-Pham, LT	en_US
dc.contributor.author	Nguyen, UDT	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Journal of Clinical Endocrinology and Metabolism, 2014, 99 (1), pp. 30 - 38	en_US
dc.identifier.issn	0021-972X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115400
dc.description.abstract	Context: Body weight is the most important anthropometric determinant of bone mineral density (BMD). Body weight is mainly made up of lean mass (LM) and fat mass (FM), and which component is more important to BMD has been a controversial issue. Objective: This study sought to compare the magnitude of association between LM, FM, and BMD by using a meta-analytic approach. Data Source: Using an electronic and manual search, we identified 44 studies that had examined the correlation between LM, FM, and BMD between 1989 and 2013. These studies involved 20 226 men and women (4966 men and 15 260 women) aged between 18 and 92 years. We extracted the correlations between LM, FM, and BMD at the lumbar spine, femoral neck, and whole body. The synthesis of correlation coefficients was done by the random-effects meta-analysis model. Results: The overall correlation between LM and femoral neck BMD (FNBMD) was 0.39 (95% confidence interval, 0.34 to 0.43), which was significantly higher than the correlation between FM and FNBMD (0.28; 95% confidence interval, 0.22 to 0.33). The effect of LM on FNBMD in men (r = 0.43) was greater than that in women (r = 0.38). In premenopausal women, the effect of LM on BMD was greater than the effect of FM (r=0.45 vs r=0.30); however, in postmenopausal women, the effects of LM and FM on BMD were comparable (r = 0.33 vs r = 0.31). Conclusion: LM exerts a greater effect on BMD than FM in men and women combined. This finding underlines the concept that physical activity is an important component in the prevention of bone loss and osteoporosis in the population. (J Clin Endocrinol Metab 99: 30-38, 2014). © Copyright 2014 by The Endocrine Society.	en_US
dc.relation.ispartof	Journal of Clinical Endocrinology and Metabolism	en_US
dc.relation.isbasedon	10.1210/jc.2013-3190	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.subject.mesh	Adipose Tissue	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Thinness	en_US
dc.subject.mesh	Organ Size	en_US
dc.subject.mesh	Body Composition	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Young Adult	en_US
dc.title	Association between lean mass, fat mass, and bone mineral density: A meta-analysis	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	99	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	99	en_US

Abstract:

Context: Body weight is the most important anthropometric determinant of bone mineral density (BMD). Body weight is mainly made up of lean mass (LM) and fat mass (FM), and which component is more important to BMD has been a controversial issue. Objective: This study sought to compare the magnitude of association between LM, FM, and BMD by using a meta-analytic approach. Data Source: Using an electronic and manual search, we identified 44 studies that had examined the correlation between LM, FM, and BMD between 1989 and 2013. These studies involved 20 226 men and women (4966 men and 15 260 women) aged between 18 and 92 years. We extracted the correlations between LM, FM, and BMD at the lumbar spine, femoral neck, and whole body. The synthesis of correlation coefficients was done by the random-effects meta-analysis model. Results: The overall correlation between LM and femoral neck BMD (FNBMD) was 0.39 (95% confidence interval, 0.34 to 0.43), which was significantly higher than the correlation between FM and FNBMD (0.28; 95% confidence interval, 0.22 to 0.33). The effect of LM on FNBMD in men (r = 0.43) was greater than that in women (r = 0.38). In premenopausal women, the effect of LM on BMD was greater than the effect of FM (r=0.45 vs r=0.30); however, in postmenopausal women, the effects of LM and FM on BMD were comparable (r = 0.33 vs r = 0.31). Conclusion: LM exerts a greater effect on BMD than FM in men and women combined. This finding underlines the concept that physical activity is an important component in the prevention of bone loss and osteoporosis in the population. (J Clin Endocrinol Metab 99: 30-38, 2014). © Copyright 2014 by The Endocrine Society.

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http://hdl.handle.net/10453/115400