A Low-Cost Multi-Electrode Array System for the Simultaneous Acquisition of Electrophysiological Signal and Cellular Morphology

Chang, Y-J; Liao, L-D; Lin, C-T; Lai, H-Y; Chen, J-L; Yang, Y-T; Ting, Y-C; Huang, Y-P; Wu, R; Thakor, NV; Chen, Y-Y

A Low-Cost Multi-Electrode Array System for the Simultaneous Acquisition of Electrophysiological Signal and Cellular Morphology

Chang, Y-J Liao, L-D Lin, C-T

Lai, H-Y Chen, J-L Yang, Y-T Ting, Y-C Huang, Y-P Wu, R Thakor, NV Chen, Y-Y

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Publisher:: Ingenta
Publication Type:: Journal Article
Citation:: Journal of neuroscience and neuroengineering, 2012, 1 (2), pp. 131 - 142
Issue Date:: 2012-12-01

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Field	Value	Language
dc.contributor.author	Chang, Y-J	en_US
dc.contributor.author	Liao, L-D	en_US
dc.contributor.author	Lin, C-T https://orcid.org/0000-0001-8371-8197	en_US
dc.contributor.author	Lai, H-Y	en_US
dc.contributor.author	Chen, J-L	en_US
dc.contributor.author	Yang, Y-T	en_US
dc.contributor.author	Ting, Y-C	en_US
dc.contributor.author	Huang, Y-P	en_US
dc.contributor.author	Wu, R	en_US
dc.contributor.author	Thakor, NV	en_US
dc.contributor.author	Chen, Y-Y	en_US
dc.date.issued	2012-12-01	en_US
dc.identifier.citation	Journal of neuroscience and neuroengineering, 2012, 1 (2), pp. 131 - 142	en_US
dc.identifier.issn	2168-2011	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115671
dc.description.abstract	This study aimed to develop a low-cost multichannel neural recording system and multi-electrode array (MEA) chip for a number of research laboratories. Because these elaborate systems may be cost-prohibitive for many laboratories, the simple fabrication of the MEA chip and the construction of the low-cost recording system with cellular image acquisition is presented in this study. The MEA chip is a polyimide-based microelectrode array with 60 electrodes (5 μm thick, 30 μm in radius and with 200 μm spacing) and is based on the semiconductor process and advanced microelectro-mechanical system (MEMS) technology. The three-dimensional (3D) structure of the electrodes is fabricated by electroplating, which produces rough textures that increased the effective surface area. The in vitro impedance of the electrodes on the MEA chip is 0.43±0.024 MΩ at 1 kHz, which is sufficiently low for obtaining high-quality neural recordings. A self-built amplifier (79 dB) and filter (100 Hz∼5 kHz) were implemented for signal conditioning. Furthermore, with the help of the National Instruments system and LabVIEW graphic interface, multichannel neural signals and cellular images can be simultaneously acquired using this low-cost neural recording system. With good biocompatibility, a high and stable SNR for neural recording, and a high tolerance for chemical and electrolytic erosion, the laboratory-designed MEA-based recording can serve as a useful device in neuroscience research.	en_US
dc.publisher	Ingenta	en_US
dc.relation.ispartof	Journal of neuroscience and neuroengineering	en_US
dc.relation.isbasedon	10.1166/jnsne.2012.1025	en_US
dc.title	A Low-Cost Multi-Electrode Array System for the Simultaneous Acquisition of Electrophysiological Signal and Cellular Morphology	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	1	en_US
utslib.for	0906 Electrical and Electronic Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Computer Science
pubs.organisational-group	/University of Technology Sydney/Strength - CAI - Centre for Artificial Intelligence
utslib.copyright.status	closed_access
pubs.consider-herdc	true	en_US
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	1	en_US

Abstract:

This study aimed to develop a low-cost multichannel neural recording system and multi-electrode array (MEA) chip for a number of research laboratories. Because these elaborate systems may be cost-prohibitive for many laboratories, the simple fabrication of the MEA chip and the construction of the low-cost recording system with cellular image acquisition is presented in this study. The MEA chip is a polyimide-based microelectrode array with 60 electrodes (5 μm thick, 30 μm in radius and with 200 μm spacing) and is based on the semiconductor process and advanced microelectro-mechanical system (MEMS) technology. The three-dimensional (3D) structure of the electrodes is fabricated by electroplating, which produces rough textures that increased the effective surface area. The in vitro impedance of the electrodes on the MEA chip is 0.43±0.024 MΩ at 1 kHz, which is sufficiently low for obtaining high-quality neural recordings. A self-built amplifier (79 dB) and filter (100 Hz∼5 kHz) were implemented for signal conditioning. Furthermore, with the help of the National Instruments system and LabVIEW graphic interface, multichannel neural signals and cellular images can be simultaneously acquired using this low-cost neural recording system. With good biocompatibility, a high and stable SNR for neural recording, and a high tolerance for chemical and electrolytic erosion, the laboratory-designed MEA-based recording can serve as a useful device in neuroscience research.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/115671