Preparation, Characterization, and In Vitro Evaluation of Nitrendipine Solid Dispersions

Gorajana, A; Rajendran, A; Dua, K; Pabreja, K; Hoon, TP

Preparation, Characterization, and In Vitro Evaluation of Nitrendipine Solid Dispersions

Gorajana, A Rajendran, A Dua, K

Pabreja, K Hoon, TP

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Publication Type:: Journal Article
Citation:: Journal of Dispersion Science and Technology, 2012, 33 (5), pp. 676 - 684
Issue Date:: 2012-05-01

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Field	Value	Language
dc.contributor.author	Gorajana, A	en_US
dc.contributor.author	Rajendran, A	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.contributor.author	Pabreja, K	en_US
dc.contributor.author	Hoon, TP	en_US
dc.date.issued	2012-05-01	en_US
dc.identifier.citation	Journal of Dispersion Science and Technology, 2012, 33 (5), pp. 676 - 684	en_US
dc.identifier.issn	0193-2691	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115767
dc.description.abstract	In order to enhance the absorption of dissolution rate of nitrendipine (NIT), solid dispersions were prepared using two water soluble carriers, polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 4000 (PEG-4000), by solvent and fusion method. The dissolution profile of solid dispersions were compared to the pure drug in both pH 1.2 hydrochloric acid and pH 6.8 phosphate buffer and the results have shown profound improvement in drug release. The solubility of solid dispersion was increased by several folds when compared to pure NIT. The physicochemical properties of the solid dispersions were examined using analytical techniques. The results of microscopic studies, x-ray powder diffraction (XRPD), and differential scanning calorimetric (DSC) analysis confirmed the amorphous state of solid dispersion in comparison to the crystalline nature of pure drug, proposing that NIT was molecularly dispersed in the polymer matrices, which were accounted for by dissolution rate enhancement. Fourier transform infrared (FTIR) spectroscopic analysis indicated the presence of hydrogen bonding between NIT and the polymers, which also explained the improvement in solubility and dissolution rate. In conclusion, solid dispersion of NIT with PVP K30 and PEG-4000 improved the solubility and rate of dissolution, which may improve the absorption of the drug and subsequently the bioavailability of NIT. © 2012 Copyright Taylor and Francis Group, LLC.	en_US
dc.relation.ispartof	Journal of Dispersion Science and Technology	en_US
dc.relation.isbasedon	10.1080/01932691.2011.579829	en_US
dc.subject.classification	Chemical Physics	en_US
dc.title	Preparation, Characterization, and In Vitro Evaluation of Nitrendipine Solid Dispersions	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	33	en_US
utslib.for	0303 Macromolecular and Materials Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	33	en_US

Abstract:

In order to enhance the absorption of dissolution rate of nitrendipine (NIT), solid dispersions were prepared using two water soluble carriers, polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 4000 (PEG-4000), by solvent and fusion method. The dissolution profile of solid dispersions were compared to the pure drug in both pH 1.2 hydrochloric acid and pH 6.8 phosphate buffer and the results have shown profound improvement in drug release. The solubility of solid dispersion was increased by several folds when compared to pure NIT. The physicochemical properties of the solid dispersions were examined using analytical techniques. The results of microscopic studies, x-ray powder diffraction (XRPD), and differential scanning calorimetric (DSC) analysis confirmed the amorphous state of solid dispersion in comparison to the crystalline nature of pure drug, proposing that NIT was molecularly dispersed in the polymer matrices, which were accounted for by dissolution rate enhancement. Fourier transform infrared (FTIR) spectroscopic analysis indicated the presence of hydrogen bonding between NIT and the polymers, which also explained the improvement in solubility and dissolution rate. In conclusion, solid dispersion of NIT with PVP K30 and PEG-4000 improved the solubility and rate of dissolution, which may improve the absorption of the drug and subsequently the bioavailability of NIT. © 2012 Copyright Taylor and Francis Group, LLC.

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http://hdl.handle.net/10453/115767