Dynamic association between intraocular pressure and spontaneous pulsations of retinal veins

Golzan, SM; Graham, SL; Leaney, J; Avolio, A

Dynamic association between intraocular pressure and spontaneous pulsations of retinal veins

Golzan, SM

Graham, SL Leaney, J Avolio, A

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Publication Type:: Journal Article
Citation:: Current Eye Research, 2011, 36 (1), pp. 53 - 59
Issue Date:: 2011-01-01

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Field	Value	Language
dc.contributor.author	Golzan, SM https://orcid.org/0000-0002-4479-3917	en_US
dc.contributor.author	Graham, SL	en_US
dc.contributor.author	Leaney, J	en_US
dc.contributor.author	Avolio, A	en_US
dc.date.issued	2011-01-01	en_US
dc.identifier.citation	Current Eye Research, 2011, 36 (1), pp. 53 - 59	en_US
dc.identifier.issn	0271-3683	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115815
dc.description.abstract	Purpose: The amplitude of spontaneous retinal venous pulsations (SRVP) is known to be affected by intraocular pressure (IOP), retinal venous pressure, and intracranial pressure (ICP). This study characterized SRVPs adjacent to the disc and quantified changes in the amplitude of these pulsations during IOP manipulation in normal subjects. Methods: The study included 12 subjects (40±15, 4 females, 8 males). Baseline IOP (range 10-25 mmHg) was measured and SRVP recorded using the dynamic retinal vessel analyzer (DVA). IOP was lowered using aproclonidine 0.5% and measured every 15min, followed by dynamic recording of SRVP. Two subjects were also tested with timolol 0.5%, and three were treated with a placebo drop. Mean amplitude of SRVP was determined within each sample at the same site. Blood pressure and heart rate were tracked continuously. Results: Amplitude of SRVP decreased in all subjects with reduction of IOP with aproclonidine and timolol. Mean SRVP amplitude was 8.5±6 μm at baseline and reduced to 2.5±1.8 μm after 45min (p<0.0001). IOP fell from 14.4±2.6 mmHg to 10.2±2.9 mmHg over the same period (p<0.001). Venous diameter, blood pressure, and heart rate did not change significantly from the baseline. Analysis of waveforms showed a slight phase shift only (150±78.5ms, p=0.93) between disc veins and adjacent retinal vein. Conclusion: SRVPs in the peripapillary retina have similar waveform characteristics to those at the disc. SRVP amplitudes are reduced by manipulation of IOP downwards with pharmacological intervention. The relationship was consistent in all individuals tested for two classes of drugs and was independent of BP or heart rate changes. © 2011 Informa Healthcare USA, Inc.	en_US
dc.relation.ispartof	Current Eye Research	en_US
dc.relation.isbasedon	10.3109/02713683.2010.530731	en_US
dc.subject.classification	Ophthalmology & Optometry	en_US
dc.subject.mesh	Retinal Vein	en_US
dc.subject.mesh	Pupil	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Glaucoma, Open-Angle	en_US
dc.subject.mesh	Tropicamide	en_US
dc.subject.mesh	Tonometry, Ocular	en_US
dc.subject.mesh	Blood Pressure	en_US
dc.subject.mesh	Heart Rate	en_US
dc.subject.mesh	Intraocular Pressure	en_US
dc.subject.mesh	Pulsatile Flow	en_US
dc.subject.mesh	Reference Values	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Dynamic association between intraocular pressure and spontaneous pulsations of retinal veins	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	36	en_US
utslib.for	MD Multidisciplinary	en_US
utslib.for	1113 Opthalmology and Optometry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	36	en_US

Abstract:

Purpose: The amplitude of spontaneous retinal venous pulsations (SRVP) is known to be affected by intraocular pressure (IOP), retinal venous pressure, and intracranial pressure (ICP). This study characterized SRVPs adjacent to the disc and quantified changes in the amplitude of these pulsations during IOP manipulation in normal subjects. Methods: The study included 12 subjects (40±15, 4 females, 8 males). Baseline IOP (range 10-25 mmHg) was measured and SRVP recorded using the dynamic retinal vessel analyzer (DVA). IOP was lowered using aproclonidine 0.5% and measured every 15min, followed by dynamic recording of SRVP. Two subjects were also tested with timolol 0.5%, and three were treated with a placebo drop. Mean amplitude of SRVP was determined within each sample at the same site. Blood pressure and heart rate were tracked continuously. Results: Amplitude of SRVP decreased in all subjects with reduction of IOP with aproclonidine and timolol. Mean SRVP amplitude was 8.5±6 μm at baseline and reduced to 2.5±1.8 μm after 45min (p<0.0001). IOP fell from 14.4±2.6 mmHg to 10.2±2.9 mmHg over the same period (p<0.001). Venous diameter, blood pressure, and heart rate did not change significantly from the baseline. Analysis of waveforms showed a slight phase shift only (150±78.5ms, p=0.93) between disc veins and adjacent retinal vein. Conclusion: SRVPs in the peripapillary retina have similar waveform characteristics to those at the disc. SRVP amplitudes are reduced by manipulation of IOP downwards with pharmacological intervention. The relationship was consistent in all individuals tested for two classes of drugs and was independent of BP or heart rate changes. © 2011 Informa Healthcare USA, Inc.

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http://hdl.handle.net/10453/115815