D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation.

Publication Type:
Journal Article
Biochemical and biophysical research communications, 2013, 431 (3), pp. 586 - 589
Issue Date:
Filename Description Size
1-s2.0-S0006291X13000338-main.pdfPublished Version431.8 kB
Adobe PDF
Full metadata record
We have demonstrated that D(5) and D(2) dopamine receptors exist as heteromers in cells, and determined these receptor interact through amino acids in the cytoplasmic regions of each receptor. Specifically involved in heteromer formation we identified in the carboxyl tail of the D(5) receptor three adjacent glutamic acid residues, and in intracellular loop 3 of the D(2) receptor two adjacent arginine residues. Any pairing of these three D(5) receptor glutamic acids were sufficient for heteromer formation. These identified residues in D(5) and D(2) receptors are oppositely charged and likely interact by electrostatic interactions.
Please use this identifier to cite or link to this item: