Bone mineral density and association of osteoarthritis with fracture risk

Chan, MY; Center, JR; Eisman, JA; Nguyen, TV

Bone mineral density and association of osteoarthritis with fracture risk

Chan, MY Center, JR Eisman, JA Nguyen, TV

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Publication Type:: Journal Article
Citation:: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 2014, 22 (9), pp. 1251 - 1258
Issue Date:: 2014-09-01

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Field	Value	Language
dc.contributor.author	Chan, MY	en_US
dc.contributor.author	Center, JR	en_US
dc.contributor.author	Eisman, JA	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.date.available	2014-07-10	en_US
dc.date.issued	2014-09-01	en_US
dc.identifier.citation	Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 2014, 22 (9), pp. 1251 - 1258	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115873
dc.description.abstract	Copyright © 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. OBJECTIVE: High body mass index (BMI) is associated with increased risk of osteoarthritis (OA) and reduced risk of fragility fracture. However, the relationship between fragility fracture and OA remained unclear. This study sought to investigate the effect of bone mineral density (BMD) in the OA-fracture relationship.METHODS: Data from 2412 women and 1452 men aged >45 years in the Dubbo Osteoporosis Epidemiology Study (DOES) were analyzed. Individuals have been followed for up to 22 years (median: 7.5 years; range: 0.1-22 years). Femoral neck BMD (FNBMD) and lumbar spine BMD (LSBMD) was measured by dual energy X-ray absorptiometry (DXA) (GE LUNAR, Madison, WI). The presence of OA was ascertained at baseline by self-reported diagnosis. The incidence of low-trauma fracture was ascertained from X-ray reports.RESULTS: Overall, 29% of women and 26% of men had reported a diagnosis of OA. Fracture risk was significantly higher in women with OA than those without OA (Hazard ratio (HR) = 1.50; 95% confidence interval (CI), 1.28-1.76). However, the association was mainly observed in women with osteopenic BMD (HR = 1.74; 95% CI, 1.38-2.17) and normal-BMD (HR = 1.50; 95% CI, 1.06-2.13) and not in those with osteoporosis. Further analysis revealed that osteopenic women with OA had significant increase in risk of vertebral (HR = 1.85; 95% CI, 1.24-2.75) and limb fracture (HR = 2.49; 95% CI, 1.77-3.48), but not in hip fracture. In men, no comparable relationship was found before and after adjustment for covariates.CONCLUSION: Women with OA have an increased risk of fragility fracture, and the risk was mainly observed in non-osteoporotic group.	en_US
dc.relation.ispartof	Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society	en_US
dc.relation.isbasedon	10.1016/j.joca.2014.07.004	en_US
dc.subject.classification	Arthritis & Rheumatology	en_US
dc.subject.mesh	Femur Neck	en_US
dc.subject.mesh	Lumbar Vertebrae	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Osteoporosis	en_US
dc.subject.mesh	Osteoarthritis	en_US
dc.subject.mesh	Obesity	en_US
dc.subject.mesh	Absorptiometry, Photon	en_US
dc.subject.mesh	Body Mass Index	en_US
dc.subject.mesh	Prevalence	en_US
dc.subject.mesh	Risk Assessment	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Sex Factors	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	New South Wales	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Osteoporotic Fractures	en_US
dc.title	Bone mineral density and association of osteoarthritis with fracture risk	en_US
dc.type	Journal Article
utslib.citation.volume	9	en_US
utslib.citation.volume	22	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	1106 Human Movement and Sports Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	9	en_US
pubs.publication-status	Published	en_US
pubs.volume	22	en_US

Abstract:

Copyright © 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. OBJECTIVE: High body mass index (BMI) is associated with increased risk of osteoarthritis (OA) and reduced risk of fragility fracture. However, the relationship between fragility fracture and OA remained unclear. This study sought to investigate the effect of bone mineral density (BMD) in the OA-fracture relationship.METHODS: Data from 2412 women and 1452 men aged >45 years in the Dubbo Osteoporosis Epidemiology Study (DOES) were analyzed. Individuals have been followed for up to 22 years (median: 7.5 years; range: 0.1-22 years). Femoral neck BMD (FNBMD) and lumbar spine BMD (LSBMD) was measured by dual energy X-ray absorptiometry (DXA) (GE LUNAR, Madison, WI). The presence of OA was ascertained at baseline by self-reported diagnosis. The incidence of low-trauma fracture was ascertained from X-ray reports.RESULTS: Overall, 29% of women and 26% of men had reported a diagnosis of OA. Fracture risk was significantly higher in women with OA than those without OA (Hazard ratio (HR) = 1.50; 95% confidence interval (CI), 1.28-1.76). However, the association was mainly observed in women with osteopenic BMD (HR = 1.74; 95% CI, 1.38-2.17) and normal-BMD (HR = 1.50; 95% CI, 1.06-2.13) and not in those with osteoporosis. Further analysis revealed that osteopenic women with OA had significant increase in risk of vertebral (HR = 1.85; 95% CI, 1.24-2.75) and limb fracture (HR = 2.49; 95% CI, 1.77-3.48), but not in hip fracture. In men, no comparable relationship was found before and after adjustment for covariates.CONCLUSION: Women with OA have an increased risk of fragility fracture, and the risk was mainly observed in non-osteoporotic group.

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http://hdl.handle.net/10453/115873