OncoCis: annotation of cis-regulatory mutations in cancer.

Publisher:
BioMed Central
Publication Type:
Journal Article
Citation:
Genome Biology, 2014, 15 (10), pp. 1 - 14
Issue Date:
2014-10-09
Full metadata record
Files in This Item:
Filename Description Size
OncoCis: annotation of cis-regulatory mutations in cancer.pdfPublished Version3.16 MB
Adobe PDF
Whole genome sequencing has enabled the identification of thousands of somatic mutations within non-coding genomic regions of individual cancer samples. However, identification of mutations that potentially alter gene regulation remains a major challenge. Here we present OncoCis, a new method that enables identification of potential cis-regulatory mutations using cell type-specific genome and epigenome-wide datasets along with matching gene expression data. We demonstrate that the use of cell type-specific information and gene expression can significantly reduce the number of candidate cis-regulatory mutations compared with existing tools designed for the annotation of cis-regulatory SNPs. The OncoCis webserver is freely accessible at https://powcs.med.unsw.edu.au/OncoCis/.
Please use this identifier to cite or link to this item: