Dynamics of Water and Small Molecules in Bioadhesive Polymer Films

Physical Society of Japan
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Journal Article
Journal of the Physical Society of Japan, 2013, 82 pp. 1 - 8 (8)
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Using quasielastic neutron scattering, we investigated the diffusion of a model drug (lidocaine, a molecule used in local anaesthetics and anti-arrhythmics) through a novel, water soluble, transdermal film (Patch-non-Patch®). The diffusivity of lidocaine is triggered by that of water. Up to hydration levels h = 15 (weight of water/total weight in %), water molecules are bound to the polymer matrix and no long range diffusion occurs. Lidocaine diffuses only when 'mobile' water is present (h > 0.15). The diffusivity of lidocaine is about three orders of magnitude lower than that of pure water, and it does not appreciably change up to h ~ 60.
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