A dissociation between propriospinal facilitation and inhibition after bilateral transcranial direct current stimulation

McCambridge, AB; Stinear, JW; Byblow, WD

A dissociation between propriospinal facilitation and inhibition after bilateral transcranial direct current stimulation

McCambridge, AB

Stinear, JW Byblow, WD

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Publication Type:: Journal Article
Citation:: Journal of Neurophysiology, 2014, 111 (11), pp. 2187 - 2195
Issue Date:: 2014-06-01

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Field	Value	Language
dc.contributor.author	McCambridge, AB https://orcid.org/0000-0001-6822-4199	en_US
dc.contributor.author	Stinear, JW	en_US
dc.contributor.author	Byblow, WD	en_US
dc.date.issued	2014-06-01	en_US
dc.identifier.citation	Journal of Neurophysiology, 2014, 111 (11), pp. 2187 - 2195	en_US
dc.identifier.issn	0022-3077	en_US
dc.identifier.uri	http://hdl.handle.net/10453/118128
dc.description.abstract	Propriospinal premotoneurons (PN) are essential for accurate control of the upper limb. They receive bilateral input from premotor (PM) and primary motor (M1) cortices. In humans, excitability of PNs can be estimated from motor-evoked potentials (MEPs) by pairing a descending volley using transcranial magnetic stimulation (TMS) to summate with an ascending volley from peripheral nerve stimulation at the C3-C4 level of the spinal cord. Transcranial direct current stimulation (tDCS) alters excitability of cortical and subcortical areas. A recent study demonstrated that cathodal tDCS can suppress facilitatory (FAC) and inhibitory (INH) components of PN excitability, presumably via effects on corticoreticulospinal neurons (Bradnam LV, Stinear CM, Lewis GN, Byblow WD. J Neurophysiol 103: 2382-2389, 2010). The present study investigated the effects of bilateral tDCS with healthy subjects. The cathode was placed over left dorsal PM or M1 and the anode over right M1 in separate sessions (PM-M1, M1-M1, or Sham). TMS of right M1 elicited MEPs in left biceps brachii across a range of TMS intensities chosen to examine PN-mediated FAC and INH. Conditioning was applied using median nerve stimulation with an interstimulus interval that coincided with TMS and peripheral volleys summating at the C3-C4 level. All participants showed FAC at TMS intensities near active motor threshold and INH at slightly higher intensities. After tDCS, FAC was reduced for M1-M1 compared with Sham but not after PM-M1 stimulation. Contrary to an earlier study with cathodal tDCS, INH was unchanged across all sessions. The difference between these and earlier findings may relate to dual- vs. single-hemisphere M1 stimulation. M1-M1 tDCS may be a useful adjuvant to techniques that aim to reduce upper limb impairment after stroke. © 2014 the American Physiological Society.	en_US
dc.relation.ispartof	Journal of Neurophysiology	en_US
dc.relation.isbasedon	10.1152/jn.00879.2013	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Proprioception	en_US
dc.subject.mesh	Evoked Potentials, Motor	en_US
dc.subject.mesh	Neural Inhibition	en_US
dc.subject.mesh	Long-Term Potentiation	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Transcranial Direct Current Stimulation	en_US
dc.subject.mesh	Cervical Cord	en_US
dc.title	A dissociation between propriospinal facilitation and inhibition after bilateral transcranial direct current stimulation	en_US
dc.type	Journal Article
utslib.citation.volume	11	en_US
utslib.citation.volume	111	en_US
utslib.for	110317 Physiotherapy	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.issue	11	en_US
pubs.publication-status	Published	en_US
pubs.volume	111	en_US

Abstract:

Propriospinal premotoneurons (PN) are essential for accurate control of the upper limb. They receive bilateral input from premotor (PM) and primary motor (M1) cortices. In humans, excitability of PNs can be estimated from motor-evoked potentials (MEPs) by pairing a descending volley using transcranial magnetic stimulation (TMS) to summate with an ascending volley from peripheral nerve stimulation at the C3-C4 level of the spinal cord. Transcranial direct current stimulation (tDCS) alters excitability of cortical and subcortical areas. A recent study demonstrated that cathodal tDCS can suppress facilitatory (FAC) and inhibitory (INH) components of PN excitability, presumably via effects on corticoreticulospinal neurons (Bradnam LV, Stinear CM, Lewis GN, Byblow WD. J Neurophysiol 103: 2382-2389, 2010). The present study investigated the effects of bilateral tDCS with healthy subjects. The cathode was placed over left dorsal PM or M1 and the anode over right M1 in separate sessions (PM-M1, M1-M1, or Sham). TMS of right M1 elicited MEPs in left biceps brachii across a range of TMS intensities chosen to examine PN-mediated FAC and INH. Conditioning was applied using median nerve stimulation with an interstimulus interval that coincided with TMS and peripheral volleys summating at the C3-C4 level. All participants showed FAC at TMS intensities near active motor threshold and INH at slightly higher intensities. After tDCS, FAC was reduced for M1-M1 compared with Sham but not after PM-M1 stimulation. Contrary to an earlier study with cathodal tDCS, INH was unchanged across all sessions. The difference between these and earlier findings may relate to dual- vs. single-hemisphere M1 stimulation. M1-M1 tDCS may be a useful adjuvant to techniques that aim to reduce upper limb impairment after stroke. © 2014 the American Physiological Society.

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http://hdl.handle.net/10453/118128