Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease

Fisher, BE; Li, Q; Nacca, A; Salem, GJ; Song, J; Yip, J; Hui, JS; Jakowec, MW; Petzinger, GM

Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease

Fisher, BE Li, Q Nacca, A Salem, GJ Song, J

Yip, J Hui, JS Jakowec, MW Petzinger, GM

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Publication Type:: Journal Article
Citation:: NeuroReport, 2013, 24 (10), pp. 509 - 514
Issue Date:: 2013-07-10

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Field	Value	Language
dc.contributor.author	Fisher, BE	en_US
dc.contributor.author	Li, Q	en_US
dc.contributor.author	Nacca, A	en_US
dc.contributor.author	Salem, GJ	en_US
dc.contributor.author	Song, J https://orcid.org/0000-0002-9971-0541	en_US
dc.contributor.author	Yip, J	en_US
dc.contributor.author	Hui, JS	en_US
dc.contributor.author	Jakowec, MW	en_US
dc.contributor.author	Petzinger, GM	en_US
dc.date.issued	2013-07-10	en_US
dc.identifier.citation	NeuroReport, 2013, 24 (10), pp. 509 - 514	en_US
dc.identifier.issn	0959-4965	en_US
dc.identifier.uri	http://hdl.handle.net/10453/118151
dc.description.abstract	We have previously demonstrated changes in dopaminergic neurotransmission after intensive exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- lesioned mouse model of Parkinson's disease (PD), including an increase in the dopamine D2 receptor (DA-D2R), using noninvasive PET imaging with the radioligand [F]fallypride. The purpose of this feasibility and translational study was to examine whether intensive exercise leads to similar alterations in DA-D2R expression using PET imaging with [F]fallypride in individuals with early-stage PD. In this pilot study, four patients with early-stage PD were randomized to receive intensive exercise (treadmill training sessions three times/week for 8 weeks) or no exercise. Two healthy age-matched individuals participated in treadmill training. Alterations in the DA-D2R binding potential (BP) as a marker for receptor expression were determined using PET imaging with [F]fallypride. Turning performance in the patients with PD as a measure of postural control and the Unified Parkinson's Disease Rating Scale scores pre-exercise and postexercise were determined. Our data showed an exercise-induced increase in [F]fallypride BP as well as improved postural control in patients with PD who exercised. Changes in DA-D2R BP were not observed in patients with PD who did not exercise. These results suggest that exercise can lead to neuroplasticity in dopaminergic signaling and contribute to improved function that may be task specific (postural control) in early-stage PD. © 2013 Wolters Kluwer Health \| Lippincott Williams & Wilkins.	en_US
dc.relation.ispartof	NeuroReport	en_US
dc.relation.isbasedon	10.1097/WNR.0b013e328361dc13	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Brain	en_US
dc.subject.mesh	Neostriatum	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Parkinson Disease	en_US
dc.subject.mesh	Benzamides	en_US
dc.subject.mesh	Pyrrolidines	en_US
dc.subject.mesh	Receptors, Dopamine D2	en_US
dc.subject.mesh	Radiopharmaceuticals	en_US
dc.subject.mesh	Positron-Emission Tomography	en_US
dc.subject.mesh	Magnetic Resonance Imaging	en_US
dc.subject.mesh	Gait	en_US
dc.subject.mesh	Exercise Therapy	en_US
dc.subject.mesh	Pilot Projects	en_US
dc.subject.mesh	Psychomotor Performance	en_US
dc.subject.mesh	Posture	en_US
dc.subject.mesh	Neuronal Plasticity	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Biomechanical Phenomena	en_US
dc.title	Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease	en_US
dc.type	Journal Article
utslib.citation.volume	10	en_US
utslib.citation.volume	24	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	110317 Physiotherapy	en_US
utslib.for	1702 Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.issue	10	en_US
pubs.publication-status	Published	en_US
pubs.volume	24	en_US

Abstract:

We have previously demonstrated changes in dopaminergic neurotransmission after intensive exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- lesioned mouse model of Parkinson's disease (PD), including an increase in the dopamine D2 receptor (DA-D2R), using noninvasive PET imaging with the radioligand [F]fallypride. The purpose of this feasibility and translational study was to examine whether intensive exercise leads to similar alterations in DA-D2R expression using PET imaging with [F]fallypride in individuals with early-stage PD. In this pilot study, four patients with early-stage PD were randomized to receive intensive exercise (treadmill training sessions three times/week for 8 weeks) or no exercise. Two healthy age-matched individuals participated in treadmill training. Alterations in the DA-D2R binding potential (BP) as a marker for receptor expression were determined using PET imaging with [F]fallypride. Turning performance in the patients with PD as a measure of postural control and the Unified Parkinson's Disease Rating Scale scores pre-exercise and postexercise were determined. Our data showed an exercise-induced increase in [F]fallypride BP as well as improved postural control in patients with PD who exercised. Changes in DA-D2R BP were not observed in patients with PD who did not exercise. These results suggest that exercise can lead to neuroplasticity in dopaminergic signaling and contribute to improved function that may be task specific (postural control) in early-stage PD. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

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http://hdl.handle.net/10453/118151